Arrhythmia Flashcards
1
Q
Class 1 drugs?
A
Sodium channel blockers
2
Q
Class 1A drugs?
A
Procainamide
3
Q
Class 1B drugs?
A
Lidocaine
4
Q
Class 1C drugs?
A
Flecainide
5
Q
MOA of Procainide?
A
“1. Slows Phase 0 depolarization
2. Slows conductivity and automaticity
3. Increases ERP and APD
6
Q
MOA of Lidocaine?
A
- Slow Phase 0 rise
- Shorten Phase 3 repolarization
- Lower Automaticity, little effect on conductivity
- Lower APD
- No change in ERP
7
Q
MOA of Flecainide
A
- Lower rate of Phase 0 rise
- Shorten phase 3 repolarization
- Reduce conductivity + automaticity
- No/little effect on APD + ERP
8
Q
Use of Flecainide?
A
Refractory Ventricular tachycardias that progress to VF
9
Q
Beta blockers names?
A
Metoprolol
Propranolol
10
Q
MOA of beta blockers?
A
“1. Block binding of Beta-1 ligand to Gs protein on myocyte surface
- Reduce Phase 4 depolarization
- Reduce Automaticity
- Prolong AV conduction
- Reduce HR + contractility
- No change to APD + ERP”
11
Q
Uses of beta blockers?
A
- Tachycardia caused by sympathetic activation
- Atrial fibrillation
- AV nodal re-entrant tachycardia
- Reduce sudden arrhythmic death post-MI
12
Q
What class is beta blockers?
A
Class 2
13
Q
Class 3 drugs?
A
K channel blockers, Amiodarone
14
Q
MOA of amiodarone
A
- Block I kr and I ks (III)
- Block sodium channels (I)
- Block adrenergic receptor (II)
- Block Calcium channels (IV)
- Prolong Phase 3 repolarization (no Phase 0 effect)
- Increase ERP + APD
15
Q
ADR of amiodarone?
A
Symptomatic bradycardia
Heart block
