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Imunology > Hypersensitivity Reactions Worksheet > Flashcards

Hypersensitivity Reactions Worksheet Flashcards

1
Q

match the type of hypersensitivity to the description:
antibody mediated
a) type II
b) type IV
c) type III
d) type I

A

a) type II

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2
Q

match the type of hypersensitivity to the description:
cell mediated
a) type II
b) type IV
c) type III
d) type I

A

b) type IV

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3
Q

match the type of hypersensitivity to the description:
immune complex
a) type II
b) type IV
c) type III
d) type I

A

c) type III

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4
Q

match the type of hypersensitivity to the description:
immediate
a) type II
b) type IV
c) type III
d) type I

A

d) type I

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5
Q

describe the progression of type I hypersensitivity

A

It is an IgE mediated hypersensitivity in which first exposure causes antigen binding to B-cells which is presented to T-cells (Th2) cells. This causes isotype switching to IgE and these IgE antibodies are secreted. These antibodies bind FcεR on mast cells and basophils and upon second exposure causes degranulation and hypersensitivity reaction. Remember the role of IL-4 secreted by Th2 cells which influences B cells to switch to IgE production.

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6
Q

describe the four possible outcomes of IgG mediated type II hypersensitivity

A
  1. IgG mediated phagocytosis
  2. ADCC through NK cells
  3. Complement activation to membrane attack complex destruction of pathogen
  4. Complement activation that leads to formation of C3b and C3b mediated phagocytosis
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7
Q

describe Type III hypersensitivity

A

-antibodies become embedded in tissues (endothelial cell membranes) and attach to soluble antigens

-these now activated immune complexes attract inflammatory immune cells such as neutrophils which causes enzyme release and tissue destruction

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8
Q

describe Type IV hypersensitivity

A

it is a cell mediated immune response through Th1 cell activation of macrophages and inflammatory response

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9
Q

name the type of hypersensitivity:
arthus
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

c) type III hypersensitivity

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10
Q

name the type of hypersensitivity:
tuberculin
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

d) type IV hypersensitivity

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10
Q

name the type of hypersensitivity:
delayed skin reaction
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

d) type IV hypersensitivity

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11
Q

name the type of hypersensitivity:
transfusion reactions
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

b) type II hypersensitivity

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12
Q

name the type of hypersensitivity:
serum sickness
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

c) type III hypersensitivity

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13
Q

name the type of hypersensitivity:
autoimmune disease
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

c) type III hypersensitivity

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14
Q

name the type of hypersensitivity:
Urticaria
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

a) type I hypersensitivity

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15
Q

name the type of hypersensitivity:
Blue eye
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

c) type III hypersensitivity

16
Q

name the type of hypersensitivity:
Stevens-Johnson syndrome
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

d) type IV hypersensitivity

17
Q

name the type of hypersensitivity:
systemic anaphylaxis
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

a) type I hypersensitivity

18
Q

name the type of hypersensitivity:
Hemolytic disease of the newborn
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

b) type II hypersensitivity

19
Q

name the type of hypersensitivity:
allergic contact dermatitis
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

d) type IV hypersensitivity

20
Q

name the type of hypersensitivity:
drug-mediated
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

b) type II hypersensitivity

21
Q

name the type of hypersensitivity:
Purpura hemorrhagica
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivit

A

c) type III hypersensitivity

22
Q

name the type of hypersensitivity:
atopic dermatitis
a) type I hypersensitivity
b) type II hypersensitivity
c) type III hypersensitivity
d) type IV hypersensitivity

A

a) type I hypersensitivity

Imunology (10 decks)

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