Hypersensitivity Reactions = ACID

Question 1

What is the Hypersensitivity acronym?

Answer 1

ACID 
Anaphylactic
Cytotoxic 
Immune Complex Mediated
Delayed Hypersensitivity

Question 2

Type I

Answer 2

Anaphylactic: IgE

Rapid - Immediate!

Mast cell (histamine), Basophils

Question 3

Type II

Answer 3

Cytotoxic: IgG

Min-hours…BAD BLOOD!!

Targets cell for phagocytosis
2 things for Type 2: Antigen + Antibody

Question 4

Type III

Answer 4

Immune Complex Mediated: IgG + Complement

3-10 hours - systemic

3 things: Antigen + Antibody + Complement

Question 5

Type IV

Answer 5

Delayed Hyper-sensitivity: T Cell + Lymphocytes

48 hours

AKAS: Cell Mediated / Cellular

Question 6

Bronchial asthma

Answer 6

Anaphylactic (I)

Question 7

Graves’ disease

Answer 7

Cytotoxic (II)

HPT

Question 8

Blood transfusions

Answer 8

Cytotoxic (II)

Question 9

Myasthenia Gravis

Answer 9

Cytotoxic (II)

Question 10

Erythroblastosis fetalis

Answer 10

Cytotoxic (II)

Aka Coombs Anemia

Question 11

Goodpasteurs (lung +kidney)

Answer 11

Cytotoxic (II)

Grp A Beta Hemolytic Strep

Question 12

Glomerulonephritis

Answer 12

Immune Complex Mediated (systemic) (III)

Question 13

Lupus, RA,

Answer 13

Immune Complex Mediated (systemic) (III)

Question 14

Serum Sickness

Answer 14

Immune Complex Mediated (systemic) (III)

Question 15

Arthus Rxn = local necrosis

Answer 15

Immune Complex Mediated (systemic) (III)

Question 16

TB

Answer 16

Delayed Hypersensitivity / Cell Mediated / Cellular (IV)

Question 17

Contact Dermatitis (poison ivy)

Answer 17

Delayed Hypersensitivity / Cell Mediated / Cellular (IV)

Question 18

Transplant rejection

Answer 18

Delayed Hypersensitivity / Cell Mediated / Cellular (IV)