Hypersensitivity

Question 1

Type I Hypersensitivity

Answer 1

Immediate; involves IgE and histamine production

Question 2

Type II Hypersensitivity

Answer 2

Cytotoxic; reaction of IgG with host cell membrane or antigen absorbed by host cell membrane

example: mismatched blood transfusion

Question 3

Type III Hypersensitivity

Answer 3

Immune complex-mediated; formation of immune complex of antigen and antibody

immune complexes deposit in walls of blood vessels and results in inflammation/damage (esp in kidneys)

Question 4

Type IV Hypersensitivity

Answer 4

Delayed; reaction between sensitized T cells with antigen and release of lymphokines which activates macrophages and causes inflammation

example: poison ivy, TB, transplant rejection

Question 5

Symptoms of Type I Hypersensitivity

Answer 5

Can range from a runny nose to anaphylaxis