HYPERSENSITIVITY Flashcards
Who devised a classification system for such reactions based on four different categories
Philip George Houthem Gell
Robert Royston Amos Coombs
Cell bound antibody reacts with antigen
Type 1 hypersensitivity
Free antibody reacts with antigen
Type 2 hypersensitivity
Antibody reacts with soluble antigen
Type 3 hypersensitivity
Sensitize the cells rather than antibody and responsible for symptoms that develop
Type IV hypersensitivity
Immediate hypersensitivity is
Antibody mediated
Delayed hypersensitivity is
Cell mediated
Early phase of allergic reaction in type one hypersensitivity
Short lag time
Which hypersensitivity is connected with the complemet
Type II and type III hypersensitivity
What is the immune mediator and key reactant present in type1
IgE
Antigens that trigger for mission of IgE
Atopic antigens or allergens
Greek word “atopos” means
Out of place
Presents with itching erythema
Generalized anaphylaxis
Consists of localized, swelling, and redness
Local Anaphylaxis
Occurs when serum is transferred from allergic to non-allergic individual
Passive cutaneous Anaphylaxis
They contain histamine, rich granules and high affinity receptors for IgE
Mast Cells
Basophils
10 times greater supply per cell than basophils
Histamine
Testing for immediate hypersensitivity in vivo method
Cutaneous testing
intradermal testing
Testing for immediate hypersensitivity in Vitro methods
Radio immunosorbent test
Radioallergosorbent assay
Anti human IgE is bound to a solid phase such as (3)
Cellulose
paper disk
microtiter well
He showed that when this rabbits were challenged with an intradermal injection
Arthus reaction by Maurice Arthus 1903
Used to produce an abundance of circulating antibodies
Rabbits
Use to treat tetanus and this is benign and self limiting disease
Serum sickness
Recovery takes between
7-30 days
Th1 cells are activated and release cytokines such as (3)
Interleukin-3
interferon gamma
Tumor necrosis factor
Other name for type II hypersensitivity
Cytotoxic hypersensitivity
Time to inspected for erythema and wheal formation
15-20 minutes
Other name for type I hypersensitivity
Anaphylactic hypersensitivity
