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COMPLEMENT SYSTEM Flashcards

1
Q

Complement is a complex of more than:

A

30 SOLUBLE AND CELL-BOUND PROTEINS

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2
Q

Who gave the termed “complement”

A

PAUL EHRLICH IN 1980

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3
Q

Acute phase reactants was primarily produced within 12-24 hours by

A

HEPATOCYTES

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4
Q

Increase in certain intracellular signaling polypeptides are called:

A

CYTOKINES

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5
Q

Most plasma complement proteins are synthesized in

A

LIVER

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6
Q

Plasma Complement proteins are released in

A

ZYMOGENS

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7
Q

Complement Activation promotes (3)

A

ACTIVATION OF IMMUNE SYSTEM

OPSONIZATION

LYSIS OF FOREIGN CELLS AND IMMUNE COMPLEXES

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8
Q

Who awarded for elucidating the nature of complement

A

JULES BORDET

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9
Q

Which classical pathway is produced by epithelial cells and factor D

A

C 1

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10
Q

Alternative pathway or Properdin is stabilized by

A

C3 CONVERTASE

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11
Q

STAGES OF OS COMPLEMENT ACTIVATION CLASSICAL PATHWAY

A

RECOGNITION STAGE

ACTIVATION STAGE

FORMATION OF MAC

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12
Q

First complement component to bind is

A

C1

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13
Q

SUBUNITS OF C1

A

C1q
C1s
C1 r

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14
Q

Which subunit of C1, generate enzyme activity to begin the casscade

A

C1 r & C1s

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15
Q

C1 q form:

A

6 GLOBULAR HEADS WITH COLLAGEN TAIL LIKE PORTION

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16
Q

End product in activation stage:

A

C5 CONVERTASE

17
Q

C2 at least bound c1s at

A

60nm RADIUS

18
Q

Which component is next to be activated

19
Q

C2 a binds to c4 b to form:

A

C3 CONVERTASE

20
Q

This complex is not very stable

A

C3 CONVERTASE

21
Q

Half life of C3 convertase

A

15 secs to 3 mins

22
Q

C4 at least bound C1 s at

23
Q

C7 binds to C5b6 to form:

24
Q

C8 binds to C5b67 to form:

25
Q

C9 binds to C5b678 to form:

A

COMPLETE LYSIS OF CELL

26
Q

What is the relation between Factor B and C2

A

THEY ARE ANALOGOUS TO EACH OTHER

27
Q

Who described alternative pathway

A

PILLEMER IN 1950

28
Q

Proteins in alternative pathway (3)

A

PROPERDIN

FACTOR B

FACTOR D

29
Q

Considered as an acute phase protein

A

MANNOSE-BINDING LECTIN

30
Q

Major constituent of lectin pathway

31
Q

What are the MBL serine proteases (3)

A

MASP-1

MASP-2

MASP-3

32
Q

Which MBL pathway cleaves C4 and C2

33
Q

ASSOCIATED DISEASE IN MBL

A

SEPSIS

NEISSERIA INFECTIONS

34
Q

Associated disease in DAF and MIRL

A

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

35
Q

Acts as a co factor with 1 to inactivate C4b

A

C4- BINDING PROTEIN

36
Q

DAF stands for

A

DECAY ACCELERATING FACTOR

37
Q

MIRL stands for

A

Membrane inhibitor reactive lysis

38
Q

Complement fixation immunoglobulins (2)

IMSE (5 decks)

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