Comple Flashcards
3 subunits of C1
C1q
C1r
C1s
Opsonization complement component proteins
C3b
C4b
C5b
Sources of early complement component
C1
C2
C3
C4
C6
Which pathway is Antibody-dependent
Classical pathway
Which pathway is antibody-independent
Alternative pathway
Lectin pathway
What is the role of antibody-independent
Natural defense system
3 proteins of alternative pathway
Properdin
Factor B
Factor D
Classical pathway is triggered by
9 proteins
Complement fixation in classical pathway and most efficient
IgM
Steps in RECOGNITION STAGE
Fc region is bonded with C1q.
Cleaves the thioester bond of C1s.
Activates C1s
Distance of C2 to C1s
60nm radius
C2 is cleaved to C1s to form
C2a
C2b
Proteins that act in response to anaphylatoxin in immune system
C3a
C4a
C5a
Associated disease in C5 and C8 protein
Neisseria infections
Disease associated in MBL deficiency or Lack of MBL
Pneumonia
Sepsis
Meningococcal disease in infants
Immediate hypersensitivity
Antibody mediated & occurs in several minutes
Delayed hypersensitivity
Cell mediated & occurs in 24-72 hours
Most prominent in connective tissue
Mast cells
10% of the total weight of granular constituents
Histamine
Negative saline control and positive control of histamine
Cutaneuos testing
