Hyperlipidemia & Stable Angina

Question 1

Atherosclerosis

Answer 1

Lipid disposition, fibrosis, calcification, and plaque formation in vessels

Question 2

How do risk factors promote CVD?

Answer 2

Contributing to endothelial dysfunction

Question 3

What are the 4 high-benefit groups for statin use?

Answer 3

1. Clinical ASCVD
2. Primary elevations of LCL >190
3. DM with LDL 70-189 w/o ASCVD
4. LDL 70-189 and estimated ASCVD risk >7.5%

Question 4

Clinical feature depends on the location of atherosclerosis

Answer 4

Renal artery: kidney failure
Coronary artery: MI
Cerebral: neurological deficits

Question 5

Angina

Answer 5

Imbalance between supply and demand which can lead to MI CHF dysrhythmias, and death

Question 6

Chronic Angina

Answer 6

Pattern of chest pain that has not changed in severity or frequency over 2 months; brought on by exertion and relieved with rest

Question 7

Unstable Angina

Answer 7

Rest angina
Severe angina of new onset
Increase in severity or frequency

Question 8

Clinical manifestation of angina

Answer 8

Levine Sign: retrosternal chest pain/pressure/heaviness/fullness
ST depression on EKG
Radiating pain to neck, shoulder, jaw, l arm & shoulder

Question 9

Diagnostic Tests for stable angina

Answer 9

• Exercise EKG (only pt with moderate risk)
• Pharm Stress Test
• Echo
• Coronary angiography w/ cath

Question 10

Tx for stable angina

Answer 10

Lifestyle modification
Pharm therapy (Lower lipids, BP, anti platelet, nitrates)
Revascularization
Medical tx is cornerstone for stable angina

Question 11

Treatment for acute angina attack

Answer 11

Nitrates

Question 12

First line therapy for angina?

Answer 12

BB: prolong life in pt with coronary disease