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Clin Med 2 > Hyperlipidemia & Ischemic HD > Flashcards

Hyperlipidemia & Ischemic HD Flashcards

0
Q

statin drugs are contraindicated in?

A

liver disease

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1
Q

ATP III guidelines set goals based on?

A

LDL goal based on calculated CHD risk

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2
Q

statin drug side effects

A

myalgias
myositis
myopathy

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3
Q

bile acid sequestrant contraindications

A

familial dysbetalipoproteinemia

TGs > 400

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4
Q

niacin contraindications?

A

chronic liver disease

severe gout

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5
Q

niacin has two effects?

A

decrease LDL production

increase HDL

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6
Q

fibric acid derivative two effects?

A

lower TGs

increase HDL

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7
Q

fibric acid derivative contraindications

A

severe hepatic or renal disease

pre-existing gallstones

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8
Q

ezetimbe (zetia) MOA

A

blocks cholesterol transporter, intestinal absorption of dietary and bilary cholesterol

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9
Q

ezetimbe contraindications?

A

don’t use w/ a statin in active liver disease

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10
Q

2013 AHA/ACC guidelines emphasize?

A

reduction of atherosclerotic events

statin use for high risk people

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11
Q

atherogenesis is?

A

an inflammatory process, resulting in a “fatty streak,” the precursor to atherosclerotic plaques

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12
Q

source of vasoconstriction and occlusion?

A

vulnerable plaques rupture and a clot forms

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13
Q

Acute Coronary Syndromes (3)

A

unstable angina
NSTEMI
STEMI

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14
Q

EKG findings for UA/NSTEMI?

A

possible ST depression or T wave elevation

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15
Q

labs to distinguish b/w UA & NSTEMI

A

elevated CK-MB &/or troponin in NSTEMI- an MI has happened!

16
Q

most common cause of STEMI?

A

rupture of a vulnerable plaque causing complete occlusion

17
Q

EKG/lab findings for STEMI?

A

ST elevation

elevated cardiac enzymes

18
Q

tx for STEMI

A

MONA- Morphine, Oxygen, Nitroglycerin, Aspirin
early revascularization to limit infarct size
B-blockers, Ca2+ channel blockers, ACE inhibitors, statins

19
Q

tx differences b/w UA/NSTEMI and STEMI? (2)

A

revascularization early for STEMI, later for UA/NSTEMI

thrombolytics are contraindicated in UA/NSTEMI

20
Q

post-MI management? (4)

A

B-blockers, aspirin, ACE-I/ARB for LV dysfunction, cardiac rehab

21
Q

tx of stable angina? (3)

A

nitrates
B-blockers
Ca2+ channel blockers

Clin Med 2 (8 decks)

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