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Cardiovascular > Hyperlipidemia > Flashcards

Hyperlipidemia Flashcards

1
Q

Drugs used to treat hyperlipidemia:

A

HMG CoA reductase inhibitors
fibrates

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2
Q

how do HMG CoA reductase inhibitors work?

A

inhibit cholesterol synthesis

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3
Q

why is liver function required for HMG CoA reductase inhibitors to work?

A

active form of the drug generated in the liver

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4
Q

how do fibrates increase VLDL breakdown….

A

enhance lipoprotein lipase activity

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5
Q

how does reduction in VLDL decrease LDL?

A

CH cannot be transferred from HDL to VLDL to LDL

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6
Q

fibrates reduce which lipids?

A

TG and CH

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7
Q

effect of fibrates on lipoproteins?

A

increase HDL
decrease LDL

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8
Q

How do bile acid binding resins treat hyperlipidemia?

A

increase bile acid excretion, reducing CH absorption and increasing LDL receptor trasnscription

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9
Q

how does ezetimibe treat hyperlipidmeia?

A

reduced CH absorption by binding to NPC1L1

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10
Q

fibrates main action

A

increase HDL
lower TG

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11
Q

What is the main lipoprotein reduced by nicotinic acid?

A

VLDL

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12
Q

Drugs increasing HDL:

A

nicotinic acid
fibrates
statins

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13
Q

drugs having no effect on HDL:

A

bile acid binding resins

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14
Q

how does nicotinic acid decrease VLDL?

A

enhance lipoprotein lipase
decrease secretion by liver

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15
Q

What do fish oils reduce?

A

TG

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16
Q

What can fish oils increase?

A

LDL

17
Q

plant sterols activity:

A

inhibit endogenous and dietary CH absorption

18
Q

What are the targets of plant sterols?

A

LDLs and CH

19
Q

future of LDL lowering drugs…

A

PCSK9 inhibitors

20
Q

moderate intake of alcohol…

A

increases HDL

21
Q

PCSK9 inhibitors

A

prevent LDL receptor recycling

Cardiovascular (7 decks)

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