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Cardiovascular > Anti-angina drugs > Flashcards

Anti-angina drugs Flashcards

1
Q

Drugs to treat angina:

A

beta blockers
nitrates
calcium channel blockers
K channel activators

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2
Q

short acting nitrate:

A

glyceryl trinitrate

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3
Q

long lasting nitrate:

A

isosorbide mononitrate

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4
Q

how do nitrates increase oxygen supply?

A

vasodilation of collaterals + reduce ventricular pressure

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5
Q

how do nitrates decrease oxygen demand?

A

reduce afterload and preload

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6
Q

nitrate drugs activate which protein by which second messenge

A

myosin light chain phosphoatease , cGMP

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7
Q

verapamil blocks which calcium current?

A

L-type calcium current

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8
Q

how does verapmil reduce oxygen demand

A

inhibits SA and AV node conductance

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9
Q

how does verapmil reduce conductance in the SA and AV node?

A

inhibits upstroke of pacemaker potential

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10
Q

how do cardiac channel blockers increase oxygen supply?

A

increased time spent in diastole

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11
Q

how does cardiac channel blockers reduce oxygen demand?

A

reduce force and rate of contraction

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12
Q

vasculare selective calcium channels cause which vessels to dilate:

A

venous and coronary

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13
Q

by dilating the coronary vessels, how do vasculare selective calcium channel blockers treat angina?

A

dilating coronary vessels increases oxygen supply

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14
Q

by dilating the venous vessels, how do vasculare selective calcium channel blockers treat angina?

A

increase oxygen perfusion and reduce demand (work)

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15
Q

by dilating the arterial vessels, how do vasculare selective calcium channel blockers treat angina?

A

reduce work and oxygen demand

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16
Q

calcium channel blockers inhibit which enzyme?

A

mypsin light chain kinase

17
Q

how do calcium channel blockers inhinit myosin light chain kinase?

A

inhibit calcium induced calcium release

18
Q

how do beta blockers treat angina?

A

increase supply and reduce demand of oxygen

19
Q

how do beta blockers reduce demand of oxygen?

A

inhibit sympathetic activity
reduces force and rate of contraction
reduces work

20
Q

how do beta blockers increase supply of oxygen?

A

inhibit sympathetic activity
reduced heart rate
extended diastole
increased filling time

21
Q

how does nicorandil cause vasodilation?

A

K channels and nitrix oxide

22
Q

how does nicorandil decrease demand

A

vasodilation of arteries reduces afterload

23
Q

how does nicorandil increase oxygen supply?

A

vasodilation of coronary arteries

24
Q

nicorandil reduces venous return and preload and therefore reduces…

A

wall stress and increases sub endo perfusion

25
Q

activation of K channels prevents which channels from opening?

A

L-type calcium channel

26
Q

how does nicorandil increase NO

A

nitic oxide donor

Cardiovascular (7 decks)

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