atrial and pulmonary stretch receptors Flashcards

1
Q

where are stretch receptors?

A

atria
pulmonary arteries
pulmonary veins
right atrium
superior and inferior vena cava

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2
Q

which receptors respond to lower pressures?

A

cardiopulmonary stretch receptors

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3
Q

role of cardiopulmonary stretch receptors?

A

regulate blood volume (which in turn regulates cardiac output and then blood pressure)

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4
Q

effect of a drop in venous blood pressure on atrial pressure

A

atrial pressure decreases

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5
Q

what happens to the stimulation of cardiopulmonary stretch receptors when atrial blood pressure falls?

A

decreased stimulation

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6
Q

what is the relationship between ADH and cardiopulmonary stretch receptors?

A

a decrease in cardiopulmonary stretch receptor stimulation causes ADH release

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7
Q

where is ADH released?

A

hypothalamus

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8
Q

what is the effect of ADH?

A

fluid from renal tubules is reabsorbed

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9
Q

what causes the afferent renal arterioles to constrict?

A

a reflex triggered by a drop in cardiopulmonary stimulation

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10
Q

what is the effect of vasoconstriction of afferent renal arterioles?

A

glomerular filtration rate is reduced

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11
Q

how doe ADH and a reduction in glomerular filtration rate act to increase blood volume?

A

reduce fluid loss to the urine

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12
Q

how does ADH increase total peripheral resistance?

A

vasoconstriction

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13
Q

what is the set point for MAP?

A

100mmHG

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14
Q

when barroreceptors are denervated, what happens to the MAP

A

the peak remains the same but there is a larger range

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15
Q

what happens to the peak arterial pressure when baroreceptors and cardiopulmonary receptors are denervated?

A

peak MAP increases
larger range

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16
Q

where are chemoreceptors?

A

carotid and aortic bodies

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17
Q

which metabolites are chemoreceptors sensitive to?

A

oxygen carbon dioxide and hydrogen ions

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18
Q

what roles do chemoreceptors have

A

respiratory and cardiovascular regulation

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19
Q

which states stimulate chemoreceptors?

A

hypoxia hypercapnia and acidosis

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20
Q

what process do chemoreceptors stimulate?

A

sympathetically-mediated peripheral vasoconstriction

21
Q

what effect does chemoreceptor simulation have on heart rate and depth of breathing?

22
Q

what does the lung inflation reflex trigger?

A

increase in heart rate and small vasodilation

23
Q

how does chemoreceptor simulation lead to an increase in MAP?

A

increasing cardiac output and TPR

24
Q

what pathologies are chemoreceptors particularly important in?

A

asphyxia or major haemorrhage

25
what kind of effect do neural reflexes have on MAP?
short time
26
describe the lasting effect of blood volume in determining arterial pressure
long term
27
which organ is involved in blood volume regulation
kidney
28
a small increase in renal arterial pressure has what effect on urine output and glomerular filtration?
large increase
29
which system controls the relationship between arterial pressure and urine output?
renin-angiotensin-aldosterone system
30
what stimulates the renin-angiotensin-aldosterone system
decrease in blood volume or renal blood flow
31
what does the kidney release in response to drop in blood pressure?
renin
32
renin converts angiotensinogen into what?
angiotensin 1
33
what is the role of ACE?
converts angiotensin 1 into angiotensin 2
34
what is the effect of angiotensin 2?
increases thirst and vasoconstriction aldosterone release
35
where is aldosterone released
kidney
36
how does aldosteorne increase blood pressure
increases salt and water retention therefore more water is absorbed
37
what drugs are used to treat hypertension?
ACE inhibitors
38
vasoconstriction has what effect on TPR?
increases
39
what effect does increase in blood volume have on cardiac output?
increases
40
how does adrenaline increase cardiac output?
through increasing stroke volume and heart rate
41
effect of sympathetic innervation from preganglionic fibres?
adrenaline and noradrenaline release
42
which receptors mediate the effect of adrenaline?
beta adrenoreceptors
43
adrenaline targets of action:
SAN ventricular muscle
44
how does noradrenaline increase
raising TPR via vasoconstriction via alpha adrenoreceptors
45
what is the effect of ANP on MAP?
decrease
46
how does ANP decrease MAP?
vasodilation and increasing excretion of sodium in the kidneys
47
describe the release of ANP
atrial cells release ANP when cardiac filling pressures are high
48
why does NO have little effect on MAP?
acts locally