Hyperlipidaemia

Question 1

Hyperlipidaemia Definition

Answer 1

-Raised serum levels of total cholesterol, LDL cholesterol and/or triglycerides

Question 2

Hyperlipidaemia Epidemiology

Answer 2

• UK population has one of the highest serum cholesterol levels
• 2/3 have cholesterol greater than 5.2
• Heterozygous familial phypercholesterolaemia is one of the most common familial conditions

Question 3

Hyperlipidaemia Aetiology

Answer 3

• Inherited: familial; dyslipidaemias, hypercholesterolaemia, hyperlipidaemia, apoprotein disorders
• Secondary: medical conditions (hypothyroidism jaundice, Cushing’s…), drugs e.g. thiazide diuretics, glucocorticoids, Ciclosporin,, pregnancy, obesity, alcohol abuse

Question 4

Hyperlipidaemia Assessment

Answer 4

• Measure both TChol and HDL-C to achieve best estimate of CVD risk
• Measure full lipid profile