HYPERHIDROSIS

Question 1

How are sweat glands innervated?

Answer 1

post ganglionic sympathetic fibers release ACh instead of NE onto sweat glands

Question 2

describe the process of fluid secretion leading to hyperhidrosis?

Answer 2

ACh binds to cell and increases intracellular Ca2+, this activates K+ Cl- channels mediating K+ Cl- and H2O efflux–> cell shrinkage

then Na+, K+, Cl- come into cell causing Na+ to be kicked out via Na+/K+ ATPase–>Na+ to move paracellularly (water follows Na+, lots of sweating)