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N544 > Hypercholesterolemia Drugs > Flashcards

Hypercholesterolemia Drugs Flashcards

1
Q

HMG-CoA Reductase Inhibitors

A

Atorvastatin, rosuvastatin, simvastatin, lovastatin
lower LDL the most
Mechanism: results in increased LDL uptake
PK: PO at night
AE: myopathies, rhabdomyolysis

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2
Q

Bile Acid Sequestrants

A

Colesevelam, cholestyramine, colestipol
Mechanism: binds bile acids and prevents absorption, excretion of cholesterol
PK: cannot be absorbed from GI tract
AE: GI side effects

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3
Q

Fibrates

A

Gemfibrozil, fenofibrate, fenofibric acid
lower VLDLs
Mechanism: inhibit hepatic extraction of free fatty acids
AE: Gi disturbances

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4
Q

Ezetimibe

A

Mechanism: inhibits dietary cholesterol absorption
PK: PO
AE: myopathy/rhabdomyolysis, hepatitis, pancreatitis, thrombocytopenia

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5
Q

Monoclonal Antibody (PCSK9) Inhibitors

A

Alirocumab, evolocumab
added onto -statins
Mechanism: inhibition of PCSK9 leads to freed receptors and thus increased LDL uptake
PK: subQ only
AE: hypersensitivity, immunogenicity

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6
Q

Adenosine Triphosphate-Citrate Lysase (ACL) Inhibitors

A

Bempedoic acid
Mechanism: inhibition causes decreased cholesterol synthesis
PK: PO
AE: gout risk, increased risk of tendon rupture

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7
Q

Atorvastatin

A

HMG-CoA Reductase Inhibitor

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8
Q

Rosuvastatin

A

HMG-CoA Reductase Inhibitor

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9
Q

Simvastatin

A

HMG-CoA Reductase Inhibitor

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10
Q

Lovastatin

A

HMG-CoA Reductase Inhibitor

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11
Q

Colesevelam

A

Bile Acid Sequestrant

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12
Q

Cholestyramine

A

Bile Acid Sequestrant

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13
Q

Colestipol

A

Bile Acid Sequestrant

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14
Q

Gemfibrozil

A

Fibrate

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15
Q

Fenofibrate

A

Fibrate

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16
Q

Fenofibric Acid

A

Fibrate

N544 (8 decks)

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