Hyperaldestorinsm

Question 1

Aldosterone produced in

Answer 1

> zone glomerulosa

Question 2

Physiological fun. Of aldosterone

Answer 2

Na & water retention
K, H excretion

Question 3

Regulation in aldosterone

Answer 3

① hypovolemia → ↓ GFR → : ++ renin → * + + aldosterone
② ↓ BP
③ hyperkolemia

Question 4

Etiology of 2 ry hyper aldesteronism

Answer 4

Renal artery stenosis.
Renalhypoperfusion.
Cirrhosis.
Congestive cardiac Failure.
Nephrotic syndrome.
Renin-secreting tumor.
Bartter’s syndrome

Question 5

Causes of conn’s

Answer 5

• Adrenal adenoma (Conn’s syndrome)
• Bilateral adrenal hyperplasia

Question 6

CIP of conn’s

Answer 6

① mild hypertension
② hypokalemic
→ Ms weakness
→ fatigue
→ ↓ sensitivity of RT to ADH → polyuria , polydypsia
→ mild impaired glucose tolerance
③ alkalosis
→ tetany

Question 7

Potassium level in conn’s

Answer 7

In blood ↓↓
In urine Î î

Question 8

Plasma renin activity in conn’s

Answer 8

Suppressed

Question 9

Plasma aldosterone:renin ratio (ARR):

Answer 9

used as a screening
test for the condition. Drugs such as aldosterone antagonist and (ACE)
inhibitors and (ARBs) may affect results.

Question 10

Investigation of cause in conn’s

Answer 10

Abdominal CT & MRI

Question 11

TTT of conn’s

Answer 11

Surgical → adrenal tumors
Medical → hyperplasia
Low salt diet + aldosterone antagonist. ( spironolactone )