Addison

Question 1

Epidomology of Addison

Answer 1

Male= female

Question 2

Cause of primary Addison

Answer 2

X auto immune
X prolonged ingestion of glucocorticoid
X TB
X sarcoidosis & hemochromatosis’s
X tumors

Question 3

Most common cause of Addison in developed

Answer 3

Autoimmune

Question 4

Cause, of z ry adrenal in sufficiency

Answer 4

Tumor
Irradiation

Question 5

C/p of prim. Addison [

Answer 5

H H H A G I
Hypoglycemia
Hyperpigmination
Hypotension
Git (diarrhoea
Asthenia
Infertility

Question 6

Hypo glycemic in Addison

Answer 6

Absence of warning signs due to lack of adrenaline

Question 7

Hypotension in Addison

Answer 7

↓. cortisone → — sensitivity of catecholamin
↓ aldosterone → hypovolemia
Postural hypotension is common

Question 8

Sites of hyper pigmentation in Addison

Answer 8

l - sun exposed areas
Z- pressure areas
3- areola
4- recent scars
5- mucous memb..

Question 9

Cause of asthenia in Addison

Answer 9

↓ aldesterone → hyperkalemia
↓ cortisol
↓ androgen

Question 10

Synacthan test

Answer 10

→ normal → cortisol >
→ prim. Adrenal failure → cortisol <

Question 11

Investigation in Addison

Answer 11

Morning cortisol → highly suggestive

Question 12

Adrenal crises Etiology: acute on top of chronic

Answer 12

‘1 Addison, subjected to stress
‘I Z pan hypo pitulitarism ‘ if TTT with thyroxine first

Question 13

Adrenal crisis acute from start

Answer 13

Bilateral adrenal ectomy
Sudden withdraw of cortisone
Waterhouse-freid Chon

Question 14

C/p of adrenal crisis

Answer 14

Severe hypoglycomia up to coma
Severe hypotension up to shock
Severe asthenia
Severe diarrhea

Question 15

TTT of ad. Crisis

Answer 15

• 1-2 L normal saline
  *1.2 L lo% glucose
• hydrocortisone 100 mg/ 6h IV or dexamethason