Cushing

Question 1

Most common cause of Cushing

Answer 1

Exogenous glucorticoid

Question 2

Acth- dependent =

Answer 2

Disease

Question 3

Non - ACTH -D =

Answer 3

. Syndrome

Question 4

Causes of acth-d Cushing

Answer 4

• pituitary - micro adenoma
• ectopic ACTH - producing tumor
  • ACTH administration

Question 5

Pseudo Cushing

Answer 5

Chronic alcoholism → xx metabolism of corticosteroid

Question 6

Hyper pigmentation in Cushing

Answer 6

→ -ve in syndrome
→ ✓ in disease
→ -ve in ectopic

Question 7

Dexa large dose suppression test

Answer 7

→ XXX in syndrome
→ ↓ cortisone in disease
→ XXX in ectopic

Question 8

Cortisol secreted by

Answer 8

Zone fasciculata

Question 9

Action of cortisol in blood

Answer 9

↑ RBCs ↑ neutrophils
↓ lymphocytes ↓ eosinophil & basophil,

Question 10

C/p of Cushing (ptn)

Answer 10

.1 Ms wasting & weakness
2. Capillary fragility
3-ostoporosis
4 - thin skin
Stria rubra
Delayed wound healing

Question 11

Abnormal deposition of fat in Cushing

Answer 11

Moon face + acre
↑ ↑ inter-scapular fat
Truncal obesity + thin limbs

Question 12

Plethoric face in

Answer 12

Cushing

Question 13

Investigation to confirm Cushing

Answer 13

24-hr free urinary cortisol
Low dose dexa suppression test
Salivary cortisol

Question 14

if ratio in IPSS is 1:1

Answer 14

→ ectopic Cushing

Question 15

Calculation ratio in IPSS

Answer 15

Central ACTH: peripheral ACTH