humoral response Flashcards
1
Q
what are b cell receptors?
A
membrane bound antibodies
2
Q
where do b cells develop?
A
bone marrow
3
Q
what is the development stage of a b cell?
A
stem cells -> pro-B –> pre-B –> immature naive b cell –> mature naive b cell
4
Q
what are specialisations of plasma cells?
A
have more golgi and rer to secrete antibodies
5
Q
where is IgA found in abundance?
A
the gut
6
Q
what are the 5 things antibodies do?
A
agglutinisation opsonisation neutralisation killing antibody-dependent cells activation of complement
7
Q
describe the process of affinity maturation
A
b cells go to the germinal centres in the lymph nodes and spleen
they start to mutate the Fab ends of the antibody
if its a better fit to the antigen, it receives growth factors to allow it to proliferate
this continues until its the perfect fit
8
Q
explain the complement cascade
A
10 types of protein that are inactive in the body fluids become active when they detect bacteria bind to the bacteria to form a complex forms a pore in the bacteria causes it to pop so its killed
