Human Immunodeficiency Virus

Question 1

Stages of HIV Drug Class

Answer 1

1. Binding/Attachment: CCR5 Antagonists
2. Fusion: Fusion inhibitors
3. Reverse transcription: NRTIs/NRTIs
4. Integration: INSTIs
7. Bud/Mature: PIs

Question 2

Name the Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

Answer 2

Lamivudine (Epivir)
Abacavir (Ziagen)
Tenovir (Viread)
Emtricitabine (Emtriva)

Question 3

Name the Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

Answer 3

Efavirenz (Sustiva)
Rilpivirenz (Endurant)

“Virenz”

Question 4

Name the Integrase Strand Transfer Inhibitors (INSTIs)

Answer 4

Raltegravir (Isentress)
Elvitagravir (Viteka)
Dolutegravir (Tivicay)

“gravir”

Question 5

Name the Protease Inhibitors (PIs)

Answer 5

Ritonavir (Norvir)
Atazanavir (Reyetaz)
Darunavir (Prezista)

“navir”

Question 6

What are the Antiretroviral Therapy Goals?

Answer 6

1. Reduce disease progression
2. Suppress HIV viral load
3. Preserving immune function
4. Prevent transmission

Question 7

Treatment Adherence is essential to prevent drug resistance. What is the percentage?

Answer 7

95% to be effective long-term

Question 8

Recommended Regimen for pregnant women

Answer 8

2 NRTIs + PI (w/ ritonavir boost)
or
NNRTI + INSTI