HTN MoA

Question 1

thiazide diuretic

Answer 1

act on early distal tube

Question 2

potassium sparing diuretic

Answer 2

act on late distal tube

Question 3

loop diuretic

Answer 3

act on loop of henele

Question 4

selective beta1 adrenergic blockers

Answer 4

block beta1 receptors in heart
-heart doesn’t work as hard
-decrease heart rate
-decrease myocardial contractility
-slow conduction velocity
-inhibit secretion of renin from kidneys

Question 5

non selective beta adrenergic blockers

Answer 5

block beta 1 receptors in heart and beta 2 receptors in lungs

Question 6

alpha1 adrenergic blockers

Answer 6

block sympathetic receptors in arterioles
-vessels dilate

Question 7

alpha2-adrenergic agonist

Answer 7

decrease sympathetic nerve impulses from CNS to heart and arterioles
-vasodilation
-decrease heart rate

Question 8

hydralazine

Answer 8

-act directly on vascular smooth muscle to cause relaxation

Question 9

nitroprusside

Answer 9

dilation of arteries and veins
-little reflex tachycardia

Question 10

dihydropyridine calcium channel blockers

Answer 10

-highly selective for Ca channels on vascular smooth muscle
-change the shape of Ca channels in vascular smooth muscle

Question 11

nondihydropyridine calcium channel blockers

Answer 11

change shape of calcium channels in cardiac and vascular smooth muscle
-decrease BP and angina
-slow heart rate

Question 12

ACE inhibitor

Answer 12

block the conversion of angiotensin 1 to angiotensin 2
-decrease BP
-slow progression of HF
-decrease mortality

Question 13

angiotensin 2 receptor blockers

Answer 13

block antiotensin 2 from activating target receptors