HTN Flashcards

1
Q

New Diabetes Guidelines from American Diabetes Association

A
  • Less strict SBP target
  • New Target–> SBP <140 SBP
  • Lower target may be achieved if w/out undue burden
  • Does NOT mean HTN is not important for DM
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2
Q

JNC 7 Classification of HTN

A
  • Normal: SBP 159 or DBP >99
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3
Q

CV Mortality Risk

A
  • Doubles with each 20/10 mmHg increase in BP
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4
Q

BP Goals by Category

A
  • Essential HTN: <140/80
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5
Q

BP Measurement Techniques

A
  • In office: 2 readings (average), 5 minutes apart, sitting. Confirm elevated reading in contralateral arm
  • Ambulatory BP monitoring: Indicated for evaluation of ‘white-coat” HTN; Absence of 10-20% BP decrease during sleep may indicate increased CVD risk
  • Home BP: Provides information on response to therapy. May help improve adherence to therapy & evaluate “white-coat.” Avoid finger/wrist cuffs.
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6
Q

Home BP Measurements: Why & How

A
  • Better predictor of cardiovascular risk, target organ damage
  • Helps reduce “white coat” effect & determine the presence of masked HTN
  • Should be a routine component of BP measurement for monitoring someone with known or suspected HTN
  • Use upper arm, appropriate sized cuff, seated, in AM & PM for 1-week
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7
Q

Home BP Measurement: Who & What

A
  • Most patients are suitable for HBPM, except those with A-Fib or other cardiac rhythm disturbances which make automatic BP monitoring unreliable
  • Need 12 readings on average to make clinical decisions
  • Average usually considered normal if majority of findings are SBP <135/85
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8
Q

HBPM: Protocol

A
  • 5 consecutive days (minimum)
  • perform 3 measurements, 5min apart, in the AM and PM
  • Toss the first 2 days and the first measurement each days thereafter
  • Average remaining measurements
  • Average the 2nd and 3rd measurements of each triplicate set
  • Bring all recordings to HCP
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9
Q

Systolic Blood Pressure

A

Increases with age

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10
Q

Measuring BP in Elderly

A
  • An auscultatory gap is more common in elders
  • Period during which sounds of the true SBP fade away and reappear at a lower pressure point
  • Usually occurs with vascular disease
  • Often a common reason for inaccurate BPs (underestimates SBP)
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11
Q

HTN and Elders

A
  • HTN affects most elders
  • More likely to have organ damage
  • Optimal BP in HTN pts. NOT definitely established
  • Proven benefits of treating HTN in >70yrs
  • Risk of adverse outcomes by age & BP vary:
  • 140 increases risks
  • > 69: J Curve effect; risk of adverse events increase at SBP below upper 130s and above upper 140s
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12
Q

BP Goals for the Very Elderly

A
  • GOAL = 79 is beneficial:
  • Decreases BP (~15/6mmHg)
  • Decreases fatal and non-fatal stroke by 30%
  • Decreases death from stroke by 39%
  • Decreases death from any cause by 21%
  • Decreases death from CV cause by 23%
  • Decreases rate of HF by 64%
  • ** No significant difference in K, uric acid, glucose, and creatinine
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13
Q

JNC 7 Treatment Algorithm Stage 1

A

1) Lifestyle modifications

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14
Q

Stage I HTN (Without compelling indications)

A
  • SBP 140-159 or DBP 90-99
    1) Thiazide diuretic
    2) May consider ACE-I, ARB, BB, CCB, or combo
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15
Q

Stage II HTN (without compelling indications)

A
  • SBP >159 or DBP >99

1) 2 drug combo (usually thiazide diuretic + ACE-I or ARB, BB, or CCB)

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16
Q

HTN Treatment with compelling indications

A
  • Diuretics, ACE-I, ARB, CCB, and BB as needed
17
Q

Lifestyle modifications

A
  • Weight reduction: SBP -5-20mmHg/10kg
  • DASH diet: -8-14mmHg
  • Na Reduction: -2-8mmHg
  • Physical activity: -4-9mmHg
  • Moderate ETOH Consumption: -2-4mmHg
18
Q

ETOH Consumption

A
  • Guidelines for men: 24oz beer, 10oz wine, 3oz liquor
  • Guidelines for women: 1/2 of men
  • Average BP reduction: SBP -4mmHG; DBP -2.5mmHG
19
Q

Compelling indications per JNC 7

A
  • High CVD risk: thiazide, ACE-I, CCB
  • Post-MI: BB, ACE-I, aldosterone antagonist
  • HF: Thiazide, BB, ACE-I, ARB, Aldosterone antagonist
  • DM: Thiazide, BB, ACE-I, ARB, CCB
  • CKD: ACE-I, ARB
  • Recurrent stroke prevention: Thiazide, ACE-I
20
Q

C.R.A.P - Secondary HTN

A
  • Congenital Heart Disease
  • Renal Disease
  • Aldosterone problem
  • Pregnancy
21
Q

HTN: Choosing the right med

A
  • If no compelling indications: thiazide diuretic
  • If particular compelling indications: use list from JNC7
  • Choose one of “5i important classes”: ACE, ARB, BB, CCB, Diuretic
  • Simple A/CD strategy per Canadian study: ACE/ARB, CCB, & Diuretic
  • Combo agent:
  • 1 is diuretic
  • 1 is RAAS blocker
  • 1 is CCB
22
Q

HTN: ESH and AHA Guidelines

A
  • No 1 choice for BP reduction
  • Goal <130/80 for CHD, DM, and CKD
  • 5 important classes: ACE, ARB, BB, Diuretic, CCB
23
Q

HTN: Using combo meds

A
  • double combo:
  • Dual RAAS blocker (ARB/DRI): Only use for severe HF, advanced chronic renal disease w/ heavy proteinuria
  • RAAS blocker + HCTZ
  • RAAS blocker + CCB (amlodipine)
  • Triple combo (2 available): ARB, CCB (amlodipine), + HCTZ
24
Q

Uncontrolled HTN

A
  • 2 categories:
  • Difficult-to-treat HTN: Issues w/measurement and adherence, suboptimal therapy, white coat HTN
  • Truly resistant HTN: Volume overload, interfering substances, associated factors, secondary HTN
25
Q

Evaluating White Coat HTN

A
  • Validate office measurement w/HBPM
  • 24hr monitoring:
  • Continue current therapy if 135/85 then increase therapy
26
Q

Resistant HTN

A
  • BP remains elevated despite 3 anti-HTN agents

- 1 agent should be diuretic

27
Q

Resistant HTN: Volume Overload

A
  • Expansion of ECV is contributing factor (relative or absolute)
  • May NOT show up as peripheral edema
    1st Step) Increase thiazide diuretic
    2nd step) Convert to more potent diuretic
    3rd Step) Loop diuretic: if creatinine >1.5-1.8 or GFR <30
28
Q

Resistant HTN: Interfering Substances

A
  • Common: ETOH; NSAIDs and COX-2 inhibitors; OCs; some antidepressants; sympathomimetics; stimulants
  • Less common: steroids; cyclosporine; erythropoietin; natural licorice; chewing tobacco; MAOIs; Ginseng, Ephedra, Ma huang, bitter orange; tacrolimus
29
Q

Resistant HTN: Associated or Contributing Factors

A
  • Older patient: isolated systolic HTN; Tx goals based on age
  • Heavy ETOH
  • Obesity: Issues of increased Na and fluid retention; Stimulation of SNS and RAAS; Higher doses of meds often needed; Impact of weight loss; Weight loss strategies (caloric restriction, Orlistat, bariatric surgery)
30
Q

Secondary HTN: Chronic Kidney Disease

A
  • Tx should include:
  • Dietary Na restriction
  • Diuretic; RAAS blocker
  • Monitor labs w/in 2wk and q6mo
  • Increase of <5.5 is OK
31
Q

Secondary HTN: Primary hyperaldosteronism

A
  • Clues:
  • Fatigue; hypokalemia; not responsive to K supplementation
  • Many will have NL K levels
  • Diagnostic: Plasma aldosterone/renin ratio
  • Ratio 20 w/ aldosterone level >15 ng/dL suggests primary hyperaldosteronism
  • Need Dx confirmed by another test to distinguish bilateral adrenal hyperplasia from adrenal adenoma
  • Abnormal response to sodium loading
  • CT or MRI
  • Tx for Prim. hyperaldosteronism 2/t bilateral adrenal hyperplasia: aldosterone antagonist, ACE, or ARB
  • Spironolactone/Eplerenone (if gynecomastia develops
  • Surgery if adrenal adenoma
32
Q

Secondary HTN: OSA

A
  • Clues: Hx of snoring, witnessed apnea, excessive daytime sleepiness
  • Referral: polysomnography
  • Tx: CPAP, BiPAP
33
Q

Secondary HTN: Other causes

A
  • Cushing’s disease
  • Coarctation of aorta
  • Renal artery stenosis
  • Thyroid Dz
  • Hyperparathyroidism
  • Pheochromocytoma
34
Q

HTN: Intensification of Meds

A

1) optimize diuretic therapy
2) add spironolactone
3) add: alpha-blocker, combined alpha/beta-blocker, or clonidine, guanfacine, or hydralazine
4) Add 4th agent by compelling indications

35
Q

HTN: When to refer to specialist

A
  • When secondary cause of HTN is suspected

- If BP remains elevated after 6mo of therapy

36
Q

HTN: Pearls

A
  • Lifestyle modifications for ALL
  • If on 3 meds, need a balance of: vasodilator (ACE, ARB, DH-CCB), negative chronotrope (BB or NDH-CCB), & diuretic
  • For those with resistant HTN: screen for common causes of HTN; consider adding spironolactone (-20/10)