HS Flashcards
1
Q
Blood Film
A
Spherocytes
2
Q
Test for determining if its HS
A
Osmotic Fragility Test
Exposure to range of NaCl
Sonner the haemolysis = greater the fragility
3
Q
Clinical Presentation
A
Pallor / jaundice /splenomegaly / family history
4
Q
Treatment
A
Splenectomy
Cholecystectomy for gall stones
Phototherapy for neonatal jaundice
5
Q
What is mutated in HS
A
Spectri - Cytoskeleton protein
ankyrin - transmembrane proteins
6
Q
What protein is reduced that binds to haemoglobin
What happens to this in HS
A
Haptoglobin
Decreased
