HRT in Menopause Flashcards
define perimenopause
what are sx?
the period of a woman’s life shortly before the occurrence of the menopause
irregular menses, vasomotor sx, vaginal dryness, sleep disturbances, possible increase in FSH
how is menopause diagnosed?
what influences sx severity?
before 2002, what therapy were postmenopausal using and what were they used to prevent?
FSH levels b/w 30-40
the speed at which it occurs… faster = more sx
HRT: hyperlipidemia, heart disease, osteoporosis, and alzheimers
what is a black box warning for HRT?
why should progesterone be taken continuously?
increased risk of endometrial cancer with unopposed estrogen
prevent breakthrough bleeding
what was the result from women using hormone therapy compared to placebo in the trial discussed?
what about the use of estrogen therapy?
increased risk of CVD and other negative outcomes
estrogen therapy was more comparable to placebo
what diagnoses are contraindicated with HRT?
liver damage
vascular disease
hypercoag
severely elevated TGL
abnormal vaginal bleeding
current or past breast cancer
what are concerning diagnoses when considering HRT?
migraine w/ aura
history of VTE
gallbladder disease
elevated TGL
when would you prescribe ET over HT?
if pt does not have a uterus— progestin not needed to prevent endometrial cancer caused by estrogen monotherapy
what is Ospemifene used for?
what is a SE?
dyspareunia (painful intercourse)
hot flashes
what is an upcoming HRT?
Fezolinetant: neurokinin 3 receptor antagonist
T/F HRT need to be tapered in order to d/c
true
