HRM W4 Uterine Smooth Muscle Control Pharmacology

Question 1

a) Oxytocin (pitocin)

Answer 1

comes from posterior pituitary and can induce labor, reduce postpartum bleeding and release milk from mammary glands

Question 2

Dinoprostone, Dinoprost, Misoprostol

Answer 2

b) Prostaglandins that induce labor

i) Dinoprostone also ripens cervix

Question 3

c) Ergonovine (ergometrine)

Think endoMETRIum

Answer 3

reduces post-partum uterine bleeding

i) Never given to induce labor

Question 4

d) Ergotamine

Answer 4

vasoconstrictor used for headache

Question 5

i) Terbutaline

Answer 5

ß2 agonists

a) Tocolytic agents reduce/limit intracellular Ca2+ levels or reduce phosphorylation of myosin light chain

Question 6

ii) Magnesium Sulfate

Answer 6

competes with Ca2+

a) Tocolytic agents reduce/limit intracellular Ca2+ levels or reduce phosphorylation of myosin light chain

Question 7

iii) Nifedipine

Answer 7

Ca2+ channel blocker

a) Tocolytic agents reduce/limit intracellular Ca2+ levels or reduce phosphorylation of myosin light chain

Question 8

iv) Atosiban

Answer 8

oxytocin receptor antagonist

a) Tocolytic agents reduce/limit intracellular Ca2+ levels or reduce phosphorylation of myosin light chain

Question 9

v) Indomethacin

Answer 9

cycloxygenase inhibitor so decreases prostaglandin synthesis.

a) Tocolytic agents reduce/limit intracellular Ca2+ levels or reduce phosphorylation of myosin light chain

Question 10

a) Oxytocics

Answer 10

either promote labor or limit bleeding post-labor

Question 11

b) Tocolytics

Answer 11

reduce uterine contractility