HRM W3 Antineoplastic Hormones and Related Drugs

Question 1

i) Goserelin

Answer 1

a) GnRH receptor agonist

Question 2

ii) Leuprolide

Answer 2

a) GnRH receptor agonist

Question 3

i) Degarelix

Answer 3

b) GnRH antagonist

Question 4

i) Aminoglutethimide

Answer 4

c) Global steroidogenesis inhibitor

blocks pregneonlone synthesis

Question 5

ii) Abiraterone acetate

Answer 5

c) Global steroidogenesis inhibitor

blocks17 alpha hydroxylase inhibitor

Question 6

i) Dutasteride

Answer 6

d) 5 a reductase inhibitor

Question 7

ii) Finasteride

Answer 7

d) 5 a reductase inhibitor

Question 8

i) Bicalutamid

Answer 8

e) Androgen receptor antagonist

Question 9

ii) Flutamide

Answer 9

e) Androgen receptor antagonist

Question 10

b) Anastrazole

Answer 10

9) Aromatase inhibitor

a) Prevent the conversion of testosterone to estradiol 17 b and androstendione to estrone

Question 11

c) Exemestane

Answer 11

9) Aromatase inhibitor
a) Prevent the conversion of testosterone to estradiol 17 b and androstendione to estrone

NOTE: irreversibly inhibits enzyme

Question 12

a) Tamoxifen

Answer 12

10) Selective estrogen receptor modulator (SERM)

Question 13

raloxifene

Answer 13

10) Selective estrogen receptor modulator (SERM)

Question 14

tormifene

Answer 14

10) Selective estrogen receptor modulator (SERM)

Question 15

a) Fluvestrant

Answer 15

11) Selective estrogen receptor downregulator (SERD)