HPV vaccine 2

Question 1

what are some advancement in HPV vaccines and treatments

Answer 1

Second generation vaccines ,novel therapeutic strategies and lessons from SARS-CoV -2 vaccine development

Question 2

What are types of vaccines used in modern medicine

Answer 2

Oxford /AstraZeneca - Adenovirus based
Moderna /Pzifer /BioNtech -mrna based
Novavax -protein based

Question 3

What percentage of vaccine uptake is needed fro potential HPV eradication

Answer 3

At least 85% uptake globally

Question 4

What challenges exist for HPVvaccination programs

Answer 4

HPV related cancers are hard to diagnose
Global disparities in vaccine distribution
Vaccine hesistancy due to safety concerns and misinformation

Question 5

What was a major case that fueled HPV vaccine hesistancy

Answer 5

A 2009 NHS trust case involving a 14 yr old girls death ,later found unrelated to the vaccine

Question 6

What are the limitations of first generation HPV vaccines

Answer 6

Gardasil and Cervarix do not covver all oncogenic HPV strains
30% of cervical cancers may not be prevented
Coinfections with HPV strains like HPV45 reduce effectiveness

Question 7

What is gardasil and why is it an improvement

Answer 7

It covers additional HPV types for broader protection

Question 8

What new technologies are being explored for HPV vaccines

Answer 8

RNA vaccines
L1 and L2 protein based vaccines for expanded strain protection
E.coli produced vaccines for cost reduction
Microneedle patches for painless delivery

Question 9

What is the goal of therapuetic HPV vaccines

Answer 9

To tigger an immune response in an already infected individuals using viral DNA ,proteins or peptide based vaccines targeted E6/E7 oncogenes

Question 10

WHat are RNA aptamer based therapies for HPV

Answer 10

RNA aptamers bind oncoproteinns (E6/E&) to induce apotosis
Highly specific ,non immunogenic approach to treating HPV infected cells

Question 11

What are additional antivirals approaches for HPV treatment

Answer 11

E1 helicase inhibitors (block viral replication)
E2 host interaction inhibitors (prevent viral persistence)
Therapeutic microwaves (potential experimental treatment)

Question 12

Why is improving global vaccination efforts crucial

Answer 12

To reduce disparities ,increase coverage and prevent HPV related cancers worldwide