HCV pathogenesis Flashcards
What percentage of acute HCV infections lead to chronic liver disease?
Over 85% of cases
Why does HCV often lead to chronic infection?
A strong immune response fails to clear the virus leading to persistent liver damage
Long term risks of HCV infection
Cirrosis and HCC (hepitatis carcinnoma)
Symptoms of Hepitiatis
Jaundice ,abdominal swelling ,dark urine ,fatigue and nausea
WHat happens in chronic HCV cases?
Fibrosis ,cirrosis and liver failure
What percentage of HCV infections lead to mild hepatitis?
50%
what percentage of HCV infections progress to chronic infections
85%
How does HCV affect insulin metabolsim?
It disrupts insulin signalling ,increasing the risk of type 2 diabetes and metabolic syndrome.
How does HCV interact with lipids ?
It associates with lipid droplets and induces fatty liver/Steatosis
Which genotype is associated with fatty liver disease
genotype 3
What percentage of HCC cases are linked to HCV or HBV
70%
Which HCV proteins contribute to cancer development?
Core ,NS3 ,NS5A and NS5B
What are the major consequences of chronic HCV infection?
Long term liver damage and increased risk of liver cancer
How have advances in research helped HCV treatment.
Molecular tools jave improved understanding of HCV pathogenesis and therapy
