HPV pathogenesis Flashcards
what percentage of human cancers are caused by HPV?
Approximately 5%
Which cancers are most associated with HPV ?
Cervical , anogenital and oropharyngeal cancers
What are the 3 major factors influencing HPV pathogenicity?
Viral factors , host genetics and enviromental factors
What are the 3 oncogenic proteins of high risk HPVs?
E5 E6 and E7
What is the function of E7 protein ?
It binds and disrupts RB family tumour repressors , leading to uncontrolled cell division.
How does the E6 protein contribute to oncogenesis?
It promotes p53 degradation via E6-AP , preventing growth arrest and apoptosis.
What is the role of the E5 protein contribute to oncogenesis ?
It aids in immune evasion and enhances epidermal growth factor (EGFR ) signalling.
How does HPV DNA integration contribute to cancer progression?
It disrupts E2 regulation , leading to the overexpression of E6 and E7.
What are the key risk factors for cervical cancer?
Persistent HPV infection, multiple sexual partners , smoking ,contraceptive use and immune impression .
How does HPV affect the Hippo pathway ?
It manipulates YAP1 a crucial component in regulating cell growth.
What is the economic burden of HPV related treatment and prevention annually?
Approx 9 billion dollars
What is the natural history of HPV infection
Most infections resolve ,but high risk types can lead to dysplasia and invasive cancer
Why is HPV research important for cancer biology ?
It provides insight into tumour suppressor pathways and cell transformation mechanisms.
