HCV therapy Flashcards
How does interferon treatment work in HCV?
Activates antiviral pathways often combined with Ribvirin .
WHy is IFN-a or albuferon used ?
They have a longer halflife which means less frequent dosing is needed.
How long does IFN based therapy last?
24-48 weeks depending on the HCV genotype
What are the common side effects of IFN based therapy?
Neutropenia,anaemia,fatigue,nausea
What di direct acting antivrals(DAA) target?
Viral enzymes and structural proteins
What is the limitation of DAAs
Resistance can develop rapidly due to HCV high mutation rate
What are 3 main classes of daas
NS3/4A protease inhibitors
NS5A inhibitors
NS5B polymerase inhibitors
Why dooes HCV develop resistance to DAAs
HIgh error rate during replication leads to genetic diversity
How does DAA resistance develop?
Selective pressure from drugs promotes resistant varients
How is resistance to DAAs minimised ?
Combination therapies targeting multiple viral components
What is VOSEVI and how does it work
It is a combination of NS5B,NS5A ,NS3 .
It is used for resistant strains
WHat is MAVYRET?
A combination of NS3 and NS5a
What is the cure rate for modern DAA therapies ?
95-99%
What is a major limiation ot these therapies
High cost limits global acsess
What are the key challeneges in HCV treatment?
High cost inn low income countries
Reistance in certain genotypes
Expanding treatment access through global health initiatives
