HPV vaccine 1 Flashcards
How much does HPV vacccine development cost
Approximately 1 billion
How does HPV vaccines work
They provide a safe mimic of viral epitopes to trigger an immune response
What are HPV vaccines made of
Virus like particles composed of L1 capsid proteins
Why are VLPs in HPV vaccines non-infectious
They lack genetic material
What HPV types does gardasil protect against?
HPV 16,18 (high risk ) and HPV 6 ,11 (low risk , causing genital warts)
What is the difference between Cervarix and Gardasil
- Cervarix :Covers HPV 16,18 made in insects cells , ASO4 adjuvant
Gardasil - Covers HPV 16,18 , 6 ,11 made in yeast :alum based adjuvant
When was the UK national HPV vaccination program introduce
2008- for 12-13 year old girls
what majjor change was made to the Hpv vaccine schedule in 2014
Shifted from 3 doses to 2 doses
What is the primary diagnostic method for HPV related cervical abnormalities
Cytology (pap smear ),detecting koilocytes
What diagnostic method detects HPV DNA in cervical samples
HPV DNA testing
How does PCR help inn HPV diagnosis
It amplifies and detects HPV DNA in tissues
What is the impact of HPV screening programs in the UK ?
A 60% drop in cervical abnormalities between 1975-2005
What factors contribute to low cervical screening uptake
Lack of awareness and reluctance to attend screenings
What event temporarily increased HPV screening attendance
Public awareness after Jade Goodys case
What is conization and what are its risks
A surgical procedure to remove part of the cervix ,risks include recurrence scarring and pregnancy complications
What is Imiquimod and how does it work
A topical immune modulator that activates TLR7/TLR8 to boost immune response against hpv related conditions
What are the main takeaways regarding HPV prevention
Vaccination is highly effective, screening is essential and treatment includes surgery and immune modulating drugs
