How does the cell respond if DNA is damaged during the cell cycle? Flashcards
1
Q
How does p53 halt the cell cycle when DNA damage occurs for repairing?
A
Expresses p21CIP which inhibits cyclin B-Cdk1 to halt cell cycle
2
Q
What are some functions of caspases in apoptosis?
A
- Cleavage of actin and break down of cytoskeleton
- Cleavage of nuclear lamina, nuclear shrinkage and DNA fragmentation
3
Q
How does cell death by necrosis lead to an inflammatory response?
A
As the cell breaks down, its cellular contents are released
4
Q
How does apoptosis avoid an inflammatory response?
A
The cell breaks up into small fragments, which is essentially the cellular component enclosed in small pieces of membrane
