Cdk inhibitors and their functions Flashcards
1
Q
What do Cdk inhibitors (CDI) bind to?
A
Cyclin-Cdk complexes and block their action (hence block progression of cell cycle)
2
Q
What are the two classes of inhibitors?
A
- Inhibitors of Cdk2 (INK4)
- Cyclin dependant kinase inhibitor proteins (CIP, KIP)
3
Q
What are examples of these inhibitors?
A
p16^INK4
p21^CIP
