Cdks: Cell Cycle progression Flashcards
1
Q
What are Cdks?
A
Kinases which act on other proteins involved in the cell cycle
2
Q
What do active Cdks act on?
A
Act on different proteins to trigger events such as cell cycle entry, DNA replication, spindle assembly
3
Q
How are Cdks normally present in cells?
A
Cdks are inactive and are kept at a constant level in cells
4
Q
How do Cdks become activated?
A
- Cyclin binding allows phosphorylation of Cdk
- by Cdk activating kinase (CAK)
- activating Cdk so that it can now phosphorylate other substances
5
Q
How is the activity of Cdks co-ordinated?
A
Cyclin-Cdk complexes in one phase of the cell cycle activate those for the subsequent phase
