Hormones Flashcards
What is a hormone?
regulatory biochemical from endo glands or nerves -> systemic circulation -> affect target tissue receptors.
May -> new products or hormones
Can be peptides, proteins, steroids
Initiate feedback mechanisms
Hormone mode of action…
minute amounts
short half lives
longer lasting effects than nerves
Describe Ferguson’s reflex (draw)… what kind of response is involved?
slide 8…
GnRH is considered a …?
driver
FSH is considered a …?
stimulator
LH is considered a …?
ovulator
E2 is considered a …?
receptor
P4 is considered a …?
regulator
PG is considered a …?
terminator
Hormones from the brain…
melatonin, kisspeptin, prolactin, opioids
Hormones from the hypothalamus…
GnRH
Hormones from the pituitary…
FSH
LH
Hormones from the ovary…
Follicle (E2)
CL (P4)
Hormones from the uterus…
PGF2alpha
What are the gonadal hormones?
T4, E2, prog., inhibin, activin, AMH…
Steroid/gonadal hormone prod… chol -> oestradiol…? (remember AG’s flow chart)
chol -> preg off to prog OR preg -> testosterone -> oestradiol via aromatase
Placenta produces which hormones?
progestogens
relaxin
others…
Draw clinical summary slide & explain…
slide 20…
FSH does what exactly? LH does what exactly? (female)
FSH stimulates follicle dev. thru to antral stage then LH takes follicles thru to maturity & ovulation then lutenises Granulosa & theca intern cells to become Luteal cells
FSH does what exactly? LH does what exactly? (male)
FSH -> Sertoli cells -> E2 -> spermatogenesis, LH -> T4 -> libido & effects on spermatogenesis
Steriod hormones…
E2, Prog., T
GnRH is a … hormone?
decapeptide
FSH & LH are … hormones?
glycoprotein
Prolactin is a … hormone?
protein
Oxytocin is a …. hormone?
octapeptide
inhibin & activin are …. hormones? (as are hCG & eCG)
glycoproteins
Protein hormone action (draw)
slide 36
Steroid hormone action (draw)
slide 38 (attach to water soluble molecule -> longer half live)
What are some factors affecting hormonal action?
pattern & duration of secretion
half life of hormone
receptor density
receptor-hormone affinity
Detection methods of hormones…
ELISA
RIA
Feedback mechanisms in males…
draw (slide near end of hormone lec)