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ASC261 > Hormones > Flashcards

Hormones Flashcards

1
Q

What is a hormone?

A

regulatory biochemical from endo glands or nerves -> systemic circulation -> affect target tissue receptors.
May -> new products or hormones
Can be peptides, proteins, steroids
Initiate feedback mechanisms

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2
Q

Hormone mode of action…

A

minute amounts
short half lives
longer lasting effects than nerves

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3
Q

Describe Ferguson’s reflex (draw)… what kind of response is involved?

A

slide 8…

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4
Q

GnRH is considered a …?

A

driver

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5
Q

FSH is considered a …?

A

stimulator

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6
Q

LH is considered a …?

A

ovulator

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7
Q

E2 is considered a …?

A

receptor

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8
Q

P4 is considered a …?

A

regulator

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9
Q

PG is considered a …?

A

terminator

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10
Q

Hormones from the brain…

A

melatonin, kisspeptin, prolactin, opioids

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11
Q

Hormones from the hypothalamus…

A

GnRH

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12
Q

Hormones from the pituitary…

A

FSH

LH

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13
Q

Hormones from the ovary…

A

Follicle (E2)

CL (P4)

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14
Q

Hormones from the uterus…

A

PGF2alpha

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15
Q

What are the gonadal hormones?

A

T4, E2, prog., inhibin, activin, AMH…

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16
Q

Steroid/gonadal hormone prod… chol -> oestradiol…? (remember AG’s flow chart)

A

chol -> preg off to prog OR preg -> testosterone -> oestradiol via aromatase

17
Q

Placenta produces which hormones?

A

progestogens
relaxin
others…

18
Q

Draw clinical summary slide & explain…

A

slide 20…

19
Q

FSH does what exactly? LH does what exactly? (female)

A

FSH stimulates follicle dev. thru to antral stage then LH takes follicles thru to maturity & ovulation then lutenises Granulosa & theca intern cells to become Luteal cells

20
Q

FSH does what exactly? LH does what exactly? (male)

A

FSH -> Sertoli cells -> E2 -> spermatogenesis, LH -> T4 -> libido & effects on spermatogenesis

21
Q

Steriod hormones…

A

E2, Prog., T

22
Q

GnRH is a … hormone?

A

decapeptide

23
Q

FSH & LH are … hormones?

A

glycoprotein

24
Q

Prolactin is a … hormone?

A

protein

25
Q

Oxytocin is a …. hormone?

A

octapeptide

26
Q

inhibin & activin are …. hormones? (as are hCG & eCG)

A

glycoproteins

27
Q

Protein hormone action (draw)

A

slide 36

28
Q

Steroid hormone action (draw)

A

slide 38 (attach to water soluble molecule -> longer half live)

29
Q

What are some factors affecting hormonal action?

A

pattern & duration of secretion
half life of hormone
receptor density
receptor-hormone affinity

30
Q

Detection methods of hormones…

A

ELISA

RIA

31
Q

Feedback mechanisms in males…

A

draw (slide near end of hormone lec)

ASC261 (17 decks)

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