Hormone Replacement Therapy

Question 1

What are the benefits of oestrogen replacement therapy?

Answer 1

Decrease:
Osteoporosis
Vaginal dryness/dysparurina
Hot flushes

Question 2

What are the types of HRT?

Answer 2

Sequential - 14 days oestrogen, 14 days progesterone

Continuous - 28 days O + P

Question 3

ADRs of HRT?

Answer 3

ERT - increased risk of endometrial and ovarian cancer
HRT - increased risk of breast cancer
Increased risk of thromboembolism (stroke, PE, MI), decreased anti-thrombin 3

Question 4

How can HRT be administered?

Answer 4

Oral
Transdermal
Implant
Transvaginal
Nasal

Question 5

Androgen RT uses?

Answer 5

Testosterone implant to decrease hair loss

Question 6

What is the action of Clomiphene?

Answer 6

Induces ovulation

Decrease oestrogen -> decreased negative feedback -> increase LH and FSH

Question 7

What is the action of Tamoxifen?

Answer 7

Decreases breast cancer risk
Blocks oestrogen - stimulated myoepithelial cell division
Induces ovulation

Question 8

What is the action of RU486?

Answer 8

Partial antagonist at progesterone receptor
Increases uterus sensitivity to prostaglandins
Medical termination of pregnancy or induction of labour