hormonal control of bp Flashcards
what do you see here and what does it do
whole thing is juxtaglomerular apparatus, macula densa in distal ct and juxtaglomerular cells in afferent arterioles control water content in blood plasma
what do macula densa cells monitor
sodium concentration in dct
why might sodium levels in dct be low
low bp
what do macula densa cells cause when na is low in dct
release of prostaglandin - dilation of afferent arteriole for increased blood flow
what does the JGCs also release
renin
what is angiotensinII
vasoconstrictor
how does angiotensin II work
GPCR - phospholipase C - Ca2+ released
which vessels are most involved in vasoconstriction
arterioles
what happens when vasoconstiction happens
SVR goes up so bp goes up
what effects does angiotension II have on the kidneys
upregulates Na+ reabsorption from the PCT (Na+/H+ antiporter so you pee more acid), Na+ then crosses the cell into the interstitial fluid then back into the blood. water follows so blood volume increases
what does angiotensin iI do at the adrenals
stimulate aldosterone release
what does aldosterone do to bp. How?
stimulates Na reuptake from DCT inexchange for K+ ions
why might someone with low bp be hypokalemic
aldosterone has exchanged too much K for Na to try and fix the bp
how does angiotensin 11 work on the brain
stimulates ADH release
juxtaglomerular cells also have…
barorecpetors
