Homework 1 Flashcards

1
Q

What is the first line of defense against infection

A

unbroken skin and mucosal membranes

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2
Q

What is active immuntiy

A

Immune response triggered by infection or vaccination

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3
Q

The term delated hypsersensitivity is often used synonymously with

A

cell-mediated immunity

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4
Q

What are the components of the natural immune system

A

Inborn resistance.
phagocytes
complement
acute inflammatory response

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5
Q

Another term for “antigenic determinant” is

A

epitope

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6
Q

Antigenic substances are usually composed of

A

proteins, peptides, or large polysaccharides

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7
Q

What are important characteristics of an antigen

A

foreignness
degradability
molecular weight
structural stability
complexity

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8
Q

What substances can act as an antigen triggering an immune response

A

immunogens such as
viruses
bacteria
fungus
parasite
portion of a product (cell wall, capsule, endotoxin)
Tissue or cells from another individual

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9
Q

The chemical composition of an antibody is

A

proteins or large polysaccharides

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10
Q

Compare and contrast cell mediated immunity with humoral immunity

A

Cell mediated immunity:
delayed hypersensitivity
T-cells and phagocytes
cell-to-cell contact

Humoral immunity:
B-lymph
antibody mediated
defends against bacterial infection

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11
Q

Give two examples of passive immunity

A

Antibodies pass through the placenta
antibody containing serum (Rhogam)

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12
Q

There are two ways a person can have adaptive immunity. Name them

A

Infection or vaccination

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13
Q

List the forms of vaccinations

A

weak or attenuated cells
killed cells or viruses
extracted bacterial products
may contain only a portion of infectious agent

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14
Q

The primary antibody response is

A

lag, log, plateau, decline

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15
Q

What is an antibody? Make sure to include a description of basic structure

A

glycoproteins that combine with antigens to destroy them. Basic polypeptide structure with a 4 chain structure of heavy and light chains.

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16
Q

Highest plasma/serum concentrations in normal individuals

A

IgG

17
Q

Exists as a pentamer

A

IgM

18
Q

Mediates some types of hypersensitivity reactions

A

IgE

19
Q

When antigen/antibody complexes are formed, complement can be activated

A

IgG

20
Q

Capable of crossing the placenta

A

IgG

21
Q

Confined to the blood stream

A

IgM

22
Q

Exists as a dimer

A

IgA secretory

23
Q

An immunoglobulin in secretions

A

IgA

24
Q

Produced early in an immune response

A

IgM

25
Q

Primarily a cell membrane immunoglobulin

A

IgD

26
Q

What is the variable region of the antibody structure

A

Fragment antibody (Fab)
The tip of the Y’s that hold the antibody

27
Q

Light chains on the antibody structure are of two types. name them

A

Lambda and Kappa

28
Q

Describe an anamnestic response compared to a primary response

A

Shorter lag phase, longer plateau, more gradual decline, IgG primarily, antibody levels contain higher titer