End of chapter questions (2) Flashcards
Digestion of bacteria
Second
Increase in chemoattractants at site of tissue damage
Fourth
Ingestion of bacteria
Third
Change in direction of movement due to a chemoattractant substance
First
The function of polymorphonuclear neutrophil (PMN) leukocytes is:
Primary phagocytic cells
Mast cells are associated with
Participation in IgE hypersensitivity reactions
Chronic granulomatous disease represents a defect of
Oxidative metabolism
An alteration of phagocytic killing is associated with
Corticosteroid therapy
Mast cells have:
High concentration of histamine in the granules
Cell mediated immune response associated with humoral immunity
Defense against viral and bacterial infection
Defense against fungal and bacterial infection
Antibody production
T cell functions
Mediation of delayed-hypersensitivity reactions
Mediation of cytolytic reactions
Regulation of the immune response
T cell response is associated with
Cellular immune response
The function of B cells is
Humoral response
NK function
Antibody-dependent, cell-mediated cytotoxicity (ADCC) reaction
NK cells mediate
viral immunity
Surface membrane marker for CD4
Helper-inducer T cells
The surface membrane marker for CD8 is
Suppressor-cytotoxic T cells
Surface membrane marker for CD3 is
All or most T lymphocytes
The process of aging causes the thymus to
Decrease in size
Lose cellularity
T lymphocytes can also be referred to as
Memory cells
T lymphocyte characteristics
Can form a suppressor-cytotoxic subset
Can be helper-inducers
Can be CD4+ or CD8+
T lymphocyte immune response it’s associated with
Cellular immune response
B lymphocytes are associated with what immunity
Humoral antibody response
The appropriate function of cytotoxic or effector T cells is related to/associated with
Directly destroying target cells
Transplanted organ rejection
CD4+ marker
Regulator T cell function
Activate macrophages
Stimulate cell growth and differentiation
Antibody production and secretion of cytokines
The complement system is
A heat-labile series of plasma proteins
Composed of many proteinases
Composed of three interrelated pathways
All of the following are complement-controlling proteins except:
C1 (INH)
Factor I
Factor H
C3
C3
The three complement activation pathways converge at the point of cleavage of complement component
C3
All of the following result from complement activation except:
Decreased cell susceptibility to phagocytosis
Blood vessel dilation and increased vascular permeability
Production of inflammatory mediators
Cytolysis or hemolysis
Decreased cell susceptibility to phagocytosis
Which complement component is present in the greatest quantity in plasma
3
Classic complement activation sequence
C1 to C4 to C2 to C3 to C5 to C6789
Arrange the three stages of the classic complement pathways in the correct sequence
Recognition
Enzymatic activation
Membrane attack
At what stage does the complement system reach its full amplitude
C3
What makes up the membrane attack complex
C5b6789
The final steps (C8 and C9) in complement activation lead to
Cell lysis
Activation by antigen-antibody complexes represents
Classic pathway
Generation of an active (C3b, Bb) C3 convertase is seen in
Alternative pathway
Activation by microbial and mammalian cell surfaces occurs in
Alternative pathway
The ____ terminates in a membrane attack complex
Classic and alternative pathway
The alternative complement pathway is (can be):
Considered to be a predominantly, non-antibody-initiated pathway
Activated by factors such as endotoxinbs
