Homeostasis Flashcards
below normal range of partial pressure of oxygen
hypoxia
above normal range of partial pressure of oxygen
hyperoxia
below normal range of partial pressure of carbon dioxide
hypocapnia
above normal range of partial pressure of carbon dioxide
hypercapnia
below normal range of concentration of sodium
hyponatraemia
above normal range of concentration of sodium
hypernatraemia
below normal range of concentration of potassium
hypokalemia
above normal range of concentration of potassium
hyperkalemia
below normal range of concentration of calcium
hypocalcemia
above normal range of concentration of calcium
hypercalcemia
below normal range of concentration of glucose
hypoglycaemia
above normal range of concentration of glucose
hyperglycemia
below normal temperature
hypothermia
above normal temperature
hyperthermia
below normal pH
acidosis
above normal pH
alkalosis
control systems operate via
negative feedback - opposing the direction of change
afferent pathway
goes from stimulus/receptor toward integrating centre
efferent pathway
from integrating centre to effector
positive feedback
rare, non-homeostatic, increases the instability
positive feedback examples
blood clotting, nueronal excitation, childbirth
feed forward control
anticipatory alteration of effectors, independent of feedback
parametric feed forward control
type of feed forward control
motor learning eg. ball throwing
predictive homeostasis
anticipatory control
eg. increasing cardiac function in anticipation of exertion
postural responses
triggered centrally before voluntary movements
2 types of direct cellular communication
juxtacrine, gap junctions
5 types of cellular communication via ECF
autocrine, paracrine, endocrine, neuronal, neuroendocrine
juxtacrine cell communication
physical contact between cells
transmembrane proteins and phospholipids
gap junctions
physical contact between cells
directly connects the two cytoplasms
allows for free passage of molecules and ions
heart, some smooth muscle
autocrine signalling
cell signalling to itself
short distances <20 micrometers
monocytes use interleukin 1
paracrine signalling
other cells not in physical contact
acts on nearby cells at short distances
endocrine
long distances
transport via the blood stream
hormones binds to receptors e.g. insulin
neuronal
long distances
target
noradrenaline, acetylcholine
neuroendocrine
combined neuronal and endocrine signalling neuron secretes hormones into the blood adrenal medulla (adrenaline) and posterior pituitary (ADH and oxytocin)
baroreceptor reflex
response to increase blood pressure
low pressure pressure identified by
- Decreasing blood pressure is picked up by receptors between heart and brain
○ Barareceptors in arch of aorta are stretched less- Is the recepttors are triggered this is fed to medulla in control centre
response to increase blood pressure
- Increases cardiac output by increasing heart rate
○ Increased sypathetic and decreased parasympathetic
○ Increased secretion of epinephrine and norephrine- Increases heart rate and stroke volume
- Vasoconstricts to maintain blood pressure
- Increases blood pressure
- Stimulus is removed
blood sugar control - sugar too high
- Beta cells in pancreases detect high blood glucose level and release insulin
○ Insulin released by beta cells in pancreas- Organs take up glucose and blood glucose drops and switches off initial signal
○ Liver converts glucose to glycogen fats and proteins
○ Muscle and other cells use glucose as an evergy source, or convert it to glycogen
- Organs take up glucose and blood glucose drops and switches off initial signal
blood sugar control - glucose too low
- Pancreas alpha cells detects low blood glucose and releases glucagon which releases glucose into the blood and removes initial signal
○ Liver converts glycogen to glucose
positive feedback in childbirth
- Head of fetus pushes against cervix
- Nerve impulses from cervix transmitted to brain
- Brain stimulates pituitary gland to secrete oxytocin
- Oxytocin carried in bloodstream to uterus
- Oxytocin stimulates uterine contractions and pushes fetus toward cervix