homeostasis Flashcards
definition of hormone
chemical subtstance produced in minute amounts by glands, carried in the blood and alters the activity of target organs , and eventually broken down by liver
details of hormones
- made out of either protein or steroids (lipid)
- works with nervous system to coordinate activities in the body
exocrine vs endocrine glands
EXOCRINE GLANDS
- has ducts, produces a secretion
- etc : salivary glands, sweat glands
ENDOCRINE GLANDS
- ductless, produces hormones and secretes them into bloodstream
PANCREAS: secretes pancreatic juice and hormones (insulin and glucagon) (from cells called islet of Langerhans) thus it is both an exocrine and endocrine gland.
examples of endocrine glands
- gland : hypothalamus (produces) + pituitary gland (stores and releases)
hormone: anti-diuretic hormone (ADH)
function: osmoregulation
target organ: collecting duct in kidney nephron - gland: pancreas
hormone: insulin and glucagon
function: blood glucose regulation
target organ: insulin - liver and muscle cells
glucagon- liver cells only
definition of homeostasis
mantainance of constant internal environment
importance of homeostasis
- cells function in a narrow range of conditions , large changes causes cells to be inefficient
- homeostasis mantains a constant internal environment
how does homeostasis help with cell function
- function more efficiently in an internal environment with optimal conditions
- independence from external environment (not affected by external changes)
what is the reference point
optimal level in a homeostatic control system
components of homeostatic control system
- receptor
- control centre
- effector
what is negative feedback
mechanism that counteracts changes in internal environment and restores it back to reference point
process of negative feedback
- receptor detects stimulus (change) from reference point
- relays information to control centre
- control centre compares information with reference point
- change present ⇨ sends appropriate signal to the effector
- effector carries out appropriate response to counteract changes from reference point, causing an effect that is picked up by receptor
- relays information to control centre and returns system back to normal
why is it important to regulate glucose levels
- ideal substrate in cellular respiration
- only fuel molecule in brain
response in rise to glucose levels
1) increase in blood glucose levels above reference point of 90mg/100ml(stimulus) is detected by islets of Langerhans (receptor) in pancreas
2) triggers secretion of insulin (signal) by β cells of islet of Langerhans (control centre)
3) insulin is transported by blood to liver and muscles(effectors)
4) insulin causes:
- increases permeability of cell membrane to glucose
- increase rate of cellular respiration
- stimulates liver and muscle cells to convert excess glucose to glycogen
- decrease breakdown of glycogen to glucose
5) these actions decrease blood glucose concentration until it returns to reference point
6) return to reference point is detected by β cells in islet of Langerhans which decreases secretion of insulin
- circulating insulin is broken down by liver and excreted by kidney
response to fall in glucose levels
1) decrease in blood glucose levels below reference point of 90mg/100ml(stimulus) is detected by islets of Langerhans (receptor) in pancreas
2) triggers secretion of glucagon (signal) by α cells of islet of Langerhans (control centre)
3) glucagon is transported by blood to liver(effector)
4) glucagon causes in the liver:
- stimulates conversion of stored glycogen back to glucose
- converts non-carbohydrate sources to glucose
5) these actions increase blood glucose concentration until it returns to reference point
6) return to reference point is detected by α cells in islet of Langerhans which decreases secretion of glucagon
- circulating glucagon is broken down by liver and excreted by kidney
type 1 vs type 2 diabetes
type 1: cannot produce enough insulin
type 2: cannot respond to insulin produced