Homeobox Genes (L25)

Question 1

Hox Gene

Answer 1

Transcription Factor
60 AA DNA binding region with helix-turn-helix DNA binding domain (homeodomain)
Needed for development of Anterior-Posterior axis

Question 2

Co-Linearity

Answer 2

Anterior/3’ genes expressed first and most well defined boundaries

Question 3

Posterior Dominance

Answer 3

Posterior hox genes inhibit anterior hox genes

Question 4

Hox Overexpression

Answer 4

Anterior to posterior transformation

Question 5

Hox Knockout

Answer 5

Posterior to anterior transformation