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Pathology > Hodgkin's And Non Hodgkin's Lymphoma > Flashcards

Hodgkin's And Non Hodgkin's Lymphoma Flashcards

1
Q

Which organ is predominantly involved in Hodgkin’s lymphoma

A

Lymph nodes

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2
Q

Hodgkin’s lymphoma arises from

A

B cells - Germinal center or post germinal center

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3
Q

Which virus is associated with Hodgkin’s lymphoma

A

EBV

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4
Q

EBV secrets

A

Latent membrane protein 1 - genes upregulation - rate of proliferation increases

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5
Q

Cells seen in Hodgkin’s lymphoma

A

Reed Sternberg cells (RS cell)

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6
Q

Reed Sternberg cells appearance

A

Owl-eye appearance

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7
Q

Reed Sternberg cells are identified by which markers

A

CD15/CD30
PAX5
CD45 +ve

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8
Q

RS cells secretes

A

IL-5, TGF-beta, IL-10, m-CSF ++

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9
Q

Clinical features of Hodgkin’s lymphoma

A

Lymph node enlargement (Cervical LN commonly involved)
B Symptoms - Fever, weight loss etc

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10
Q

Paraneoplastic syndrome means

A

Paraneoplastic syndromes are rare conditions that can occur alongside cancerous tumors.
Pain in affected LN during alcohol consumption
Sec. Amyloidosis

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11
Q

Diagnosis methods in Hodgkin’s Lymphoma

A

LN Biopsy - Histopathological studies
PET/CT Scan
Excisional LN Biopsy

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12
Q

Types of Hodgkin’s Lymphoma

A

Classical
Non classical

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13
Q

CD molecules in Classical Hodgkin’s Lymphoma

A

CD15/CD30 +ve

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14
Q

CD molecules in Non classical Hodgkin’s lymphoma

A

CD15/CD30 -ve

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15
Q

Variants of Classical Hodgkin’s lymphoma

A

Nodular sclerosis HL
Mixed cellularity HL
Lymphocyte depleted HL
Lymphocyte Rich HL

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16
Q

Variant of Non classical Hodgkin’s lymphoma

A

Lymphocyte predominant HL

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17
Q

Most common variant of Hodgkin’s Lymphoma

A

Nodular sclerosis HL

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18
Q

Type of RS cells in Nodular sclerosis HL

A

Lacunar cell

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19
Q

Nodular sclerosis HL mostly involved which age group

A

Young adults

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20
Q

Lacunar cells in Nodular sclerosis HL secrets

A

TGF-beta - leads to formation of fibrotic bands on slide

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21
Q

Prognosis in case of Nodular sclerosis HL

A

Good prognosis

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22
Q

Most common HL variant seen in India

A

Mixed cellularity HL

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23
Q

Mixed cellularity HL usually involves which age group

A

Either younger adults or elderly (Bimodel distribution)

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24
Q

Mixed cellularity HL commonly associated with

A

EBV (in 70% of cases)

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25
Q

Lymphocyte depleted HL Usually affect which age group

A

Elderly

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26
Q

Lymphocyte Depleted is associated with

A

HIV
And EBV (90%)

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27
Q

Atypical histiocytes are seen in which Variant of HL

A

Lymphocyte Depleted HL

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28
Q

Prognosis of Lymphocyte Depleted HL

A

Bad prognosis bczz patient usually comes in advanced stage

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29
Q

Lymphocyte rich HL usually involves which age group

A

Elderly

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30
Q

Type of RS cells seen in Lymphocyte rich HL

A

Mononuclear subtype of RS cells

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31
Q

Overall Best prognosis in which Variant of HL

A

Lymphocyte predominant HL

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32
Q

Lymphocyte predominant HL can be identified by which markers

A

BCL-6
CD20 +ve

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33
Q

Type of RS cells seen in Lymphocyte predominant HL

A

Popcorn cell or Lympho-histiocytic cell

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34
Q

ANN - ARBOR Staging of HL

A

Stage 1 to Stage 4

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35
Q

ANN-ARBOR Stage 1 of HL

A

Single LN involvement (on one side of diaphragm)

36
Q

ANN-ARBOR Stage 2 of HL

A

2 or more LN involvement (on one side of diaphragm)

37
Q

ANN-ARBOR STAGE 3 Of HL

A

Involvement of LN on both side of diaphragm

38
Q

ANN-ARBOR Stage 4 of HL

A

Diffuse organ involvement (Spleen, Liver etc)

39
Q

Management of HL

A

Adriamycin
Bleomycin
Dacarbazine

40
Q

Immune checkpoint inhibitor therapy in HL

A

Nivolumab
Pembrolizumab

41
Q

Non HL arising from Mantle zone

A

Mantle zone Lymphoma

42
Q

Non HL arising from Marginal zone

A

Marginal zone Lymphoma

43
Q

Non HL arising from Germinal center

A

Burkitt’s lymphoma
Follicular lymphoma
Diffuse Large B cell Lymphoma

44
Q

Cell of origin of Mantle zone Lymphoma

A

Naive B cell

45
Q

Translocation seen in case mantle zone Lymphoma

46
Q

Due to t(11;14) in mantle zone Lymphoma

A

There is overactivity of BCL-1(Cylcin-D1) - Cell progress from G1 to S phase - more no. Of cells - leads to Diffuse lymphadenopathy

47
Q

Results of Flow Cytometry in Mantle zone Lymphoma

A

CD19, CD20 +ve
Cyclin-D1 overexpression
CD5 +ve , CD23 -ve

48
Q

Best marker for diagnosis of Mantle zone Lymphoma

49
Q

Origin of marginal zone Lymphoma

A

MALT(Mucosa associated Lymphoid tissue)

50
Q

Translocation seem in Marginal zone Lymphoma

51
Q

Marginal zone Lymphoma is usually associated with

A

Bacterial infection (H pylori)
Chronic antigenic stimulation(Autoimmune disorder)

52
Q

Most common indolent tumor in USA

A

Follicular Lymphoma

53
Q

Translocation seen in Follicular lymphoma

A

t(14;18) - overexpression of BCL-2

54
Q

Flow cytometry results in Follicular Lymphoma

A

CD19/CD20 +ve
BCL-2 +ve
CD5 -ve

55
Q

Follicular lymphoma can progress to

A

Diffuse large B cell Lymphoma
Burkitt’s Lymphoma

56
Q

Follicles like structures seen in Follicular lymphoma

A

Centrocytes
Centroblasts
Buttock cells

57
Q

Most common Non Hodgkin’s Lymphoma

A

Diffuse large B cell Lymphoma

58
Q

Causes of Diffuse large B cell Lymphoma

A

50% Idiopathic
30% due to BCL-6 overexpression
20% progression from Follicular lymphoma

59
Q

Flow cytometry results in Diffuse large B cell Lymphoma

A

CD10/CD19/CD20
BCL-6 Overexpression

60
Q

Subtypes of diffuse large B cell Lymphoma

A

Immunodeficiency associated
Primary effusion lymphoma

61
Q

Immunodeficiency associated subtype of DLBCL is usually associated with which virus

62
Q

Primary effusion lymphoma subtype of DLBCL associated with which virus

A

KSHV(Human herpes virus 8)

63
Q

Translocation seen in Burkitt’s Lymphoma

A

t(8;14), t(2;8) , t(8;22)

64
Q

Most common translocation seen in Burkitt’s lymphoma

65
Q

In Burkitt’s lymphoma there is overactivity of which gene

A

C-myc gene - Hyperactive nuclear transcription factors - increased proliferation

66
Q

Highest mitotic rate is seen in which non Hodgkin’s lymphoma

A

Burkitt’s lymphoma

67
Q

Tumor lysis syndrome associated with which type of Non HL

A

Burkitt’s Lymphoma

68
Q

Results of LN Biopsy in Burkitt’s Lymphoma

A

Starry sky appearance in which tumor - black background and star - macrophages

69
Q

Subtypes of Burkitt’s lymphoma

A

Endemic Burkitt’s Lymphoma
Sporadic BL

70
Q

Endemic Burkitt’s lymphoma is 100% associated with

71
Q

Endemic Burkitt’s lymphoma commonly seen in which population

A

Africans - mass in jaw bone

72
Q

In Sporadic Burkitt’s Lymphoma

A

Abdominal mass ++

73
Q

BCL-6 Overexpression is seen in which type of Non HL

A

Burkitt’s lymphoma
DLBCL

74
Q

Cell of origin in Hairy cell Leukemia

75
Q

Hairy cell Leukemia is more common in which gender

76
Q

Hairy cell Leukemia can involve which organs

A

BM, spleen or Liver - Pancytopenia

77
Q

Part of spleen affected in Hairy cell Leukemia

A

Red pulp - enlargement of spleen - increased risk of infections

78
Q

Blood examination results in Hairy cell Leukemia

A

Pancytopenia
Hairy cells - on phase contrast microscopy
TRAP Stain +ve

79
Q

Investigation of choice in Hairy cell Leukemia

A

Flow Cytometry - CD11/25/103
Annexin A1

80
Q

BM Examination results in Hairy cell Leukemia

A

Myelofibrosis - Dry tap on aspiration
Honey comb or Fried egg on BM Biopsy

81
Q

Cell of origin in Cutaneous T cell Lymphoma

A

CD4 T cell

82
Q

Sezary syndrome is seen in

A

Cutaneous T cell Lymphoma

83
Q

Cutaneous T cell Lymphoma can involve

A

Skin - Mycosis fungoides or Poutrier’s Microabscess - Epidermotropism

84
Q

Nucleus seen in Cutaneous T cell Lymphoma

A

Cerebriform nuclei

85
Q

Nucleus seen in Anaplastic large cell Lymphoma

A

Hallmark cells or horse shoe shaped nucleus

86
Q

CD Molecule involved in Anaplastic large cell Lymphoma

87
Q

Gene involved in Anaplastic Large cell Lymphoma

A

ALK gene involvement

Pathology (14 decks)

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