HIV Everything

Question 1

How many structural genes

Answer 1

3
env
gag
pol

Question 2

env

Answer 2

gp120 and gp41

Cleaved from gp160

Forms enveloped glycoproteins

Question 3

gp120/gp41

Answer 3

gp120: Docking glycoprotein (CD4+ tell attachment)
gp41: Transmembrane glycoprotein (Fusion and entry)

Acquired via budding

Question 4

gag

Answer 4

p24: Capsid protein (Conical capsid)

Question 5

pol

Answer 5

Reverse transcriptase, aspartate protease, integrase

Question 6

gp120

Answer 6

binds CD4 and co receptor (CCR5 early, or CXCR4 late)

Question 7

Homologus CCR5 mutation

Answer 7

Immunity

Question 8

Heterozygous CCR5 Mutation

Answer 8

Slower course

Question 9

DX:

Answer 9

Presumptive with ELISA, Sensitive. but not specific.

R/O HIV

Confirm w/ Western Blot (specific)

Look for antibodies to viral proteins. (falsely neg in first 1-2 months) or positive in babies (IgG across placenta)

PCR confirms in window

Question 10

PCR Viral Load

Answer 10

Determine prognosis, monitor effects of drug, Dx.

Question 11

AIDS Dx:

Question 12

Acute Infection:

Answer 12

Wide dissemination, Flu like, Fall in count.

Virus seeding lymphoid organs

Question 13

Clinical Latency

Answer 13

Feel fine, noticable titer of virus, and stable WBC, albeit lower.

Question 14

Final Crisis

Answer 14

AIDS

Question 15

Prophylaxis:

Question 16

Low grade fever, cough, HSM, tongue ulcer

Question 17

Fluffly white cottage cheese lesions

Question 18

Hairy Leukoplakia

Answer 18

Lateral tongue. EBV,doesn’t scrape

Question 19

Superficial vascular proliferation w/ neutrophils

Answer 19

Bartonella henselae

Doxycycline and macrolides

Question 20

Chronic, Water Diarrhea

Question 21

Brain Abscess

Question 22

Dementia

Answer 22

Many causes: Directly associated w/ HIV

Question 23

Encephalopathy

Answer 23

Reactivation of JC: PML

Demyelination

Question 24

Meningitis

Answer 24

India Ink+ Cryptococcus

Question 25

Retintis, possibly with esophagitis

Question 26

NH lymphoma (large cell)

Answer 26

Oropharynx, Waldeyer ring

EBV

Question 27

Primary CNS lymphoma

Answer 27

Focal or multile, differentiate from toxo

EBV

Question 28

Squamous cell carcinoma

Answer 28

HPV, anus or cervix 16 + 18

Question 29

Superficial neoplastic proliferation of vasculature

Answer 29

Lymphocytic infiltration HHV-8

Kaposi sarcoma

Question 30

INterstitial Pneuonia w/ Owl eye

Answer 30

CMV

Question 31

Invasisve aspergillosis

Answer 31

Plerutic pain, hemoptysis, infiltrates

Aspergillus fumigatus

Question 32

PCP

Question 33

Penuonia

Answer 33

> 200 S. pneuoniae

Question 34

TB like