HIV drugs Flashcards
What are the anti-retroviral subsets?
- NRTI’s
- NNRTI’s
- Protease inhibitors
- Integrase inhibitors
- Fusion inhibitors
- CCR5 antagonists
What are the two reverse transcriptase inhibitors?
Nucleoside
Non-nucleoside
What are the nucleoside reverse transcriptase inhibitors?
- Zidovudine
- Lamivudine
- Abacavir
- Emtricitabine
- Tenofovir
- Didanosine
- Stavudine
What is the mnemonic for the NRTI’s?
STALEDZ
- makes the viral DNA go stale
- BY inhibiting reverse transcriptase.
What is the MOA of NRTI’s?
Inhibit reverse transcriptase and can be incorporated into viral DNA chain and cause termination.
Analog or inhibitor so more nucleosides cannot be added.
What is unique about tenofovir?
NucleoTide reverse transcriptase inhibitor
- thus does not need to be phosphorylated to be incorporated into DNA
What is the difference between nucleosides and nucleotides?
- Sides have nitrogenous bases with sugar (Ribose or Deoxy)
- Tides contain both of those as well as a phosphate group
What are the NNRTI’s? What is the mnemonic?
- Nevirapine
- Etravirine
- Efavirenz
- Rilpivirine
- Delavirdine
NEERD
What is the MOA of NNRTI’s?
Bind directly to the reverse transcriptase at a site distinct from NRTI’s and inhibit it.
- no phosphorylation required
What are the protease inhibitors?
- Atazanavir
- Darunavir
- Fosamprenavir
- Indinavir
- Lopinavir
- Ritonavir
- Saquinavir
What is common about protease inhibitors name?
- Navirs
Navir tease a protease
What is the MOA of protease inhibitors?
Prevent post translational cleavage of Gag-Pol polyprotein.
- these proteases are needed to cleave mRNA into functional products
What are the fusion inhibitors?
Enfuviritide
What is the integrase inhibitor?
Raltegravir
What is the CCR5 antagonist and what is its subtype?
Maraviroc
- Fusion inhibitor
