HIV Flashcards
1
Q
What is the epi of HIV?
A
New HIV-1 cases:
U.S.: ~44,000 new cases annually
Worlwide: ~2 million new cases annually
People living with HIV-1 infection:
U.S.: 1.2 million people
Worldwide: 36.9 million
2
Q
What are the 3 common genes of HIV?
A
- Gag
- Pol
- Env
3
Q
What does the gag gene make?
A
Capsid proteins like p24
4
Q
What does the gene pol make?
A
- Reverse transciptase
- Protease
- Integrase
5
Q
What does the gene env make?
A
Envelope proteins
- gp120
- gp41
6
Q
what is the genome of HIV?
A
Diploid RNA
7
Q
What does gp120 bind to?
A
CD4 + t-cells
8
Q
What does gp41 bind too?
A
Chemokine receptors
- CXCR4 and CCR5
9
Q
What does CXCR4 usually bind?
A
SDF-1
- Stromal derived factor 1
- ass with HIV resistance
- binds to lymphocytes and directs their homing
