HIV drugs Flashcards

1
Q

Fusion inhibitors - MoA, Eg

A

Bind HIV fusion protein gp41

Enfuvirtide

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2
Q

Attachment inhibitors

A

Inhibit HIV co-receptors that enable entry - CCR5 CXCR4

Eg Maraviroc - CCR5

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3
Q

Nucleoside RTIs

A
Prodrugs that require phosphorylation
Then they mimic nucelotide building blocks for DNA
Lamivudine
Emtricitabine
Zidovudine
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4
Q

Nucleotide RTI

A

Only require one step of phosphorylation (cf 3 in nucleoside)
Tenofovir

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5
Q

NRTI/NtRTI SE

A

Mitochondrial DNA is more vulnerable to effects of NRTI/NtRTIs
–> lactic acidosis, lipoatrophy in the face and limbs and peripheral neuropathy

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6
Q

Non-NRTIs

A

Directly bind the HIV RT, not competitive with NRTI/NtRTI as act at different place in pathway

Efavirenz
Nevirapine
Delavirdine

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7
Q

Integration inhibitors

A

Inhibits viral integrase enzyme - prevents viral DNA integration into host genome

Raltegravir
Elvitegravir

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8
Q

Protease inhibitors

A

Block protease enzyme, HIV uses this to break up large polyproteins, required for assembly of new viral particles

HIV can still replicate, but produces immature virions that cannot infect new cells

Ritonavir

SE- hyperlipidaemia, fat redistribution, T2DM

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9
Q

Enfvirtide - class, SE

A

Fusion inhibitor, targets gp41

SE- local rxn to injection

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10
Q

Maraviroc

A

Attachment inhibitor, targets CCR5

Unknown SE

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11
Q

Zidovudine

A

NRTI
SE- general- fever, headache, GI disturbance
Specific - BM supression

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12
Q

Lamivudine

A

NRTI general SEs

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13
Q

Emtricitabine

A

NRTI - general SEs

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14
Q

Mitochondrial Toxicity

A

Stavudine

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15
Q

Peripheral Neuropathy

A

Zalcitabine, Stavudine

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16
Q

Hypersensitivity

A

Abacavir

17
Q

Tenofovir

A

NtRTI

SE bone and renal toxicity

18
Q

Efavirenz

A

NNRTI

CNS effects

19
Q

Nevirapine

A

NNRTI - Hepatitis and Rash

20
Q

Delavirdine

A

NNRTI - rash

21
Q

Raltegravir

A

Integration inhibitor

Unknown SE

22
Q

Protease inhibitor SEs

A

Hyperlipidaemias
Fat redistribution
T2DM