Complement

Question 1

Alternative pathway factors

Answer 1

Factors B/I/P

Question 2

Common and terminal pathway factors

Answer 2

C3, 5, 6, 7, 8, 9

Question 3

Triggered by immune complexes (Ab-Ag)

Answer 3

Classical pathway

Question 4

Triggered by bacterial polysaccharides (ie encapsulated)

Answer 4

Alternative pathway

Question 5

Ch50 test abnormal, AP50 normal

Answer 5

Classical pathway deficiency

Question 6

CH50 test normal, AP50 test abnormal

Answer 6

Alternative pathway deficiency

Question 7

Both CH50 and AP50 tests abnormal

Answer 7

Common/terminal pathway deficiency

Question 8

Rx of complement deficiencies

Answer 8

Vaccination, prophylactic Abx, high levels of suspicion for infection, screen family

Question 9

Classical pathway deficiency

Answer 9

Assoc with SLE as involved in immune complex removal

Question 10

Alternative pathway deficiency

Answer 10

Infection with encapsulated bacteria

SHiNE SKiS

Question 11

SHiNE SKiS

Answer 11

Strep pneumonia
Hib
N meningitidis
E. coli

Salmonella
Klebsiella
Strep group b

Question 12

C1 inhibitor deficiency

Answer 12

Hereditary angioedema

C1i deficiency leads to in kinin production –> oedema in multiple tissues, esp larynx

Question 13

Decay accelerated factor deficiency

Limits C3 &5 activation

Answer 13

Paroxysmal nocturnal haematuria

Inc RBC complement mediated lysis

Question 14

Factor H deficiency

Limits convertase formation

Answer 14

HUS

& spontaneous vascular permeability in macular degeneration

Question 15

Common pathway factors

Answer 15

C1q/r/s, C2, C4