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Autoantibodies Flashcards

1
Q

IgG anti-smooth muscle Ab,
Anti-LKM-1
Anti-SLA

A

Autoimmune hepatitis

LKM- liver kidney microsomal

SLA- soluble liver Ag

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2
Q

IgG Anti-Rh blood group Ag

A

Autoimmune haemolytic anaemia

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3
Q

IgG Anti glycoprotein IIb-IIIa or Ib-IX Ab

A

AI thrombocytopenic purpura

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4
Q

IgA
Anti-tissue transglutaminase
Anti endomysial Ab

A

Coeliac

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5
Q

IgG Anti-Ro

A

Congenital heart block in infants of mothers with SLE

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6
Q

IgA

Anti-endomysial Ab

A

Dermatitis Herpetiformis

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7
Q

IgG
Topoisomerase/Scl70
RNA Pol I, II, III
Fibrillarin

A

Diffuse cutaneous scleroderma

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8
Q

IgG

Anti-GBM

A

Goodpastures

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9
Q

IgG

Anti-TSH receptor

A

Graves’ disease

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10
Q

IgG

Ab against thyroglobulin & thyroperoxidase

A

Hashimoto’s thyroiditis

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11
Q

IgG

Anti centromere Ab

A

Limited cutaneous scleroderma (CREST)

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12
Q

pANCA

A

Microscopic polyangitis
OR
Churg Strauss (eGPA)

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13
Q

IgG

Anti-U1RNP (speckled pattern)

A

Mixed connective tissue disease

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14
Q

IgG

Anti-ACh receptor

A

Myasthenia gravis

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15
Q

IgG
Anti gastric parietal cells
Anti IF

A

Pernicious anaemia

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16
Q

IgG

Anti-Jo-1 (t-RNA synthetase)

A

Polymyositis/dermatomyositis

17
Q

IgG

Anti-mitochondrial Ab

A

Primary biliary cirrhosis

18
Q

IgG
Anti CCP
Anti RF

A

Rheumatoid Arthritis

19
Q

IgG
Anti-Ro
Anti-La
60-70% anti RF +ve

A

Sjorgens syndrome

20
Q

IgG
Abs to dsDNA + histones
Anti Ro, La, Sm
Anti U1RNP (unspeckled)

A

SLE

21
Q

IgG
Abs to glutamate decarboxylase (GAD)
And pancreatic B cells

A

DM type I

22
Q

cANCA

A

Wegeners Granulomatosis

GPA

23
Q

IgG cardio kinin and B2 glycoprotein,

Lupus anticoagulant

A

Antiphospholipid syndrome

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