Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm 1 > HIV Drugs > Flashcards

HIV Drugs Flashcards

1
Q

6 types of HIV drugs

A

Nucleoside Reverse

Transcriptase Inhibitors

Non-nucleoside Reverse

Protease Inhibitors

Integrase Inhibitors

HIV entry Inhibitors
Fusion Inhibitors
CCR5 Antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

DRUG

A

Zidovudine (Retrovir)(AZT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Zidovudine MOA

A

Inhibit reverse transcriptase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) DRUG

A

Efavirenz (Sustiva)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Efavirenz A/E

A

Rash

CNS symptoms
insomnia
dizziness
hallucinations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Efacirenz Drug interacrtions

A

Inhibits and induces Cytochrome P450 system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Treatment goals (Benefits) of Antiretrovirals (3)

A

Delay or reverse loss of immune function

Decrease AIDS-related complications

Prolong life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is HAART

A

Highly Active Antiretroviral Therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

drawbacks of HAART

A

Pricy,
long-term side effects,
serious drug interactions,
take for life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

5 classifications of ARTs

A

Reverse transcriptase inhibitors
•Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)
•Non-NRTIs (NNRTIs)

Integrase inhibitors

Protease inhibitors

Fusion inhibitors

CCR5 antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)
DRUG

A

Zidovudine (Retrovir)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Non-NRTIs (NNRTIs)

DRUG

A

Efavirenz (Sustiva)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Integrase inhibitors

DRUG

A

Raltegravir (Isentress)*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Protease inhibitor DRUG

A

Lopinavir/Ritonavir (Kaletra)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Fusion inhibitors

DRUG

A

Enfuvirtide (Fuzeon)*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

CCR5 antagonists DRUG

A

Maraviroc (selzentry)*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Can NRTIs be taken to keep mothers from passing HIV to fetus

A

YES

18
Q

T/F NRTIs have resistance and should be given with other antiretrovirals

A

True

19
Q

In combo with other drugs Zidovudine can

A

Decreases viral load
Delays onset of AIDS
Reduces symptom severity

20
Q

Zidovudine main toxicities

A

Severe anemia and neutropenia

Lactic acidosis in female or obese persons

21
Q

Efavirenz MOA

A

Inhibit reverse transcriptase

work directly against the enzyme activity so it cannot perform its function

22
Q

T/F NNRTIs given in combos

A

TRUE

23
Q

Integrase inhibitor

A

Raltegravir

24
Q

MOA of Raltegravir

A

Inhibits integrase

Blocking activity of integrase which is used to inject dna into host cell dna

25
Q

T/F raltegravir is well tolerated

A

TRue

26
Q

raltegravir drug interactions

A

Metabolized by an enzyme known as UGT

Caution with UGT inhibitors or inducers

27
Q

Lopinavir/Ritonavir (Kaletra) MOA

A

inhibits protease

The enzyme needed for viral replication

28
Q

T/F Lopinavir/Ritonavir (Kaletra) can reduce HIV viral load so low they are undectable

A

TRUE

29
Q

Adverse Effects of Lopinavir/Ritonavir (Kaletra)

A

Hyperglycemia
Lipodystrophy
Hyperlipidemia
Bone loss

30
Q

does Lopinavir/Ritonavir (Kaletra) have drug interactions

A

yes, it is metabolized by the CYP459 system

31
Q

Dosage of Enfuvirtide

A

Given SQ twice a day

32
Q

MOA of Enfuvirtide

A

Blocks entry of HIV into CD4 T cells

33
Q

Adverse effects of Enfuvirtide

A

Injection site reactions
Pneumonia
Hypersensitivity

34
Q

T/F Enfuvirtide has significant drug interactions

A

FALSE

35
Q

MOA of Maraviroc

A

blocks CCR5 which is a receptor that HIV bind with to enter in the CD4 cell so it Blocks entry into CD4 cells

36
Q

Dosage of Maraviroc

A

twice daily

37
Q

Adverse effects of maraviroc

A

Liver injury (Black Box)

38
Q

Drug interactions for maraviroc

A

A substrate of CYP 3A4

39
Q

Who should recieve ART

A

Any person living with HIV

All pregnant women who are HIV+

40
Q

PrEP (pre-exposure prophylaxis)

A

Use of antiretroviral medications

Detailed sexual and drug use history to determine risk

Determine potential barriers

Condom use

Can reduce risk of HIV transmission by greater than 90%

41
Q

PEP (Post-exposure prophylaxis)

A

Recommendations based on exposure and barriers

Treatments for non-occupational and healthcare professionals

Treatments include ART (antiretroviral therapy) for 28 days

HIV testing initially and at 6 and 12 weeks after exposure

Pharm 1 (28 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions